PJA2 (NM_014819) Human Tagged ORF Clone Lentiviral Particle

SKU RC205204L2V

Lenti ORF particles, PJA2 (mGFP-tagged) - Human praja ring finger 2 (PJA2), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: PJA2
• Synonyms: Neurodap1; RNF131
• Vector: pLenti-C-mGFP
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205204).
• ACCN: NM_014819
• ORF Size: 2124 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_014819.2
• RefSeq Size: 4878 bp
• RefSeq ORF: 2127 bp
• Locus ID: 9867
• UniProt ID: O43164
• Cytogenetics: 5q21.3
• Domains: RING
• Protein Families: Druggable Genome
• MW: 78.2 kDa
• Summary: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450).[UniProtKB/Swiss-Prot Function]