NFX1 (NM_002504) Human Tagged ORF Clone Lentiviral Particle

SKU RC204249L4V

Lenti ORF particles, NFX1 (mGFP-tagged) - Human nuclear transcription factor, X-box binding 1 (NFX1), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: NFX1
• Synonyms: NFX2; TEG-42; Tex42
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC204249).
• ACCN: NM_002504
• ORF Size: 3360 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_002504.3
• RefSeq Size: 4721 bp
• RefSeq ORF: 3363 bp
• Locus ID: 4799
• UniProt ID: Q12986
• Cytogenetics: 9p13.3
• Domains: R3H, zf-NF-X1
• Protein Families: Druggable Genome, Transcription Factors
• MW: 124.4 kDa
• Summary: MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]