Nucleophosmin (NPM1) (NM_002520) Human Tagged ORF Clone Lentiviral Particle

SKU RC203344L3V

Lenti ORF particles, NPM1 (Myc-DDK tagged) - Human nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: Nucleophosmin
• Synonyms: B23; NPM
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC203344).
• ACCN: NM_002520
• ORF Size: 882 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_002520.4
• RefSeq Size: 1449 bp
• RefSeq ORF: 885 bp
• Locus ID: 4869
• UniProt ID: P06748
• Cytogenetics: 5q35.1
• Domains: Nucleoplasmin
• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transcription Factors
• MW: 32.6 kDa
• Summary: The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]