QPRT (NM_014298) Human Tagged ORF Clone Lentiviral Particle

SKU RC202960L3V

Lenti ORF particles, QPRT (Myc-DDK tagged) - Human quinolinate phosphoribosyltransferase (QPRT), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: QPRT
• Synonyms: HEL-S-90n; QPRTase
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC202960).
• ACCN: NM_014298
• ORF Size: 891 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_014298.3
• RefSeq Size: 1575 bp
• RefSeq ORF: 894 bp
• Locus ID: 23475
• UniProt ID: Q15274
• Cytogenetics: 16p11.2
• Domains: QRPTase
• Protein Pathways: Metabolic pathways, Nicotinate and nicotinamide metabolism
• MW: 30.8 kDa
• Summary: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]