RPB2 (POLR2B) (NM_000938) Human Tagged ORF Clone Lentiviral Particle

SKU RC200440L3V

Lenti ORF particles, POLR2B (Myc-DDK-tagged)-Human polymerase (RNA) II (DNA directed) polypeptide B, 140kDa (POLR2B), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: RPB2
• Synonyms: hRPB140; POL2RB; RPB2
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200440).
• ACCN: NM_000938
• ORF Size: 3522 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_000938.1, NP_000929.1
• RefSeq Size: 3748 bp
• RefSeq ORF: 3525 bp
• Locus ID: 5431
• UniProt ID: P30876
• Cytogenetics: 4q12
• Domains: RNA_pol_Rpb2_1, RNA_pol_Rpb2_2, RNA_pol_Rpb2_3, RNA_pol_Rpb2_4, RNA_pol_Rpb2_5, RNA_pol_Rpb2_6, RNA_pol_Rpb2_7
• Protein Families: Transcription Factors
• Protein Pathways: Huntington's disease, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, RNA polymerase
• MW: 133.7 kDa
• Summary: This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]