PNPO (NM_018129) Human Tagged ORF Clone Lentiviral Particle

SKU RC200133L3V

Lenti ORF particles, PNPO (Myc-DDK tagged) - Human pyridoxamine 5'-phosphate oxidase (PNPO), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: PNPO
• Synonyms: HEL-S-302; PDXPO
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC200133).
• ACCN: NM_018129
• ORF Size: 783 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_018129.2
• RefSeq Size: 3482 bp
• RefSeq ORF: 786 bp
• Locus ID: 55163
• UniProt ID: Q9NVS9
• Cytogenetics: 17q21.32
• Domains: Pyridox_oxidase
• Protein Pathways: Metabolic pathways, Vitamin B6 metabolism
• MW: 30 kDa
• Summary: The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq, Oct 2008]