Itga2b (NM_010575) Mouse Tagged ORF Clone Lentiviral Particle

SKU MR222526L3V

Lenti ORF particles, Itga2b (Myc-DDK-tagged) - Mouse integrin alpha 2b (Itga2b), 200ul, >10^7 TU/mL

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Target Symbol: Itga2b
• Synonyms: AI172977; alphaIIb; CD41; CD41B; GpIIb
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR222526).
• ACCN: NM_010575
• ORF Size: 3099 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_010575.2, NP_034705.2
• RefSeq Size: 3437 bp
• RefSeq ORF: 3102 bp
• Locus ID: 16399
• UniProt ID: Q9QUM0
• Cytogenetics: 11 66.29 cM
• Summary: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.[UniProtKB/Swiss-Prot Function]