TBXAS1 (NM_001061) Human Untagged Clone

CAT#: SC322621

TBXAS1 (untagged)-Human thromboxane A synthase 1 (platelet) (TBXAS1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TBXAS1
• Synonyms: BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322621 CTGAGAAAGAGCACATTGTGGGGGCCCACTCCATGTGATGTTTGCTTGGTTGCCTGTTCC
  CTTTTCTACCTGCAGAGCACGGTTCCCATAAGGGCGGCGAGATCAGCCTCCTGTCTCATC
  TGGAAGACCACCACTCTGGGGTCTCAGAGGAATGATGGAAGCCTTGGGGTTTCTAAAATT
  GGAAGTGAATGGCCCCATGGTGACGGTGGCCCTGTCAGTGGCTCTCTTGGCCCTCCTGAA
  ATGGTACTCCACATCAGCATTCTCAAGACTGGAGAAGTTAGGCCTCAGACATCCCAAGCC
  TTCTCCTTTCATTGGAAACTTGACATTTTTCCGCCAGGGTTTTTGGGAAAGCCAAATGGA
  GCTCAGAAAGCTGTATGGACCTCTGTGTGGGTACTATCTTGGTCGTCGGATGTTTATTGT
  TATTTCTGAGCCAGACATGATCAAGCAGGTGTTGGTTGAGAACTTCAGTAACTTTACCAA
  CAGAATGGCGTCGGGTTTGGAGTTCAAGTCGGTAGCCGACAGCGTTCTGTTTTTACGTGA
  CAAAAGATGGGAAGAGGTCAGAGGTGCCCTGATGTCTGCTTTCAGTCCTGAAAAGCTGAA
  CGAGATGGTTCCCCTCATCAGCCAAGCCTGCGACCTTCTCCTGGCTCATTTAAAACGCTA
  TGCGGAATCTGGGGACGCATTTGACATCCAGAGGTGCTACTGCAATTACACCACAGATGT
  GGTTGCCAGCGTCGCCTTTGGCACCCCGGTGGACTCCTGGCAGGCCCCTGAGGATCCCTT
  TGTGAAACACTGCAAGCGTTTCTTCGAATTCTGCATCCCCAGACCTATCCTGGTTTTACT
  CTTATCATTTCCATCCATAATGGTCCCACTGGCCCGGATTTTGCCCAATAAGAACCGAGA
  CGAACTGAATGGCTTTTTTAACAAACTCATTAGGAATGTGATTGCCTTGCGGGACCAGCA
  AGCTGCCGAAGAGAGGCGGAGAGACTTCCTCCAAATGGTCCTGGATGCCCGACATTCTGC
  AAGTCCCATGGGCGTGCAAGACTTTGACATCGTCAGAGACGTTTTCTCCTCTACTGGGTG
  CAAGCCGAACCCTTCCCGGCAACACCAGCCCAGCCCTATGGCCAGGCCTTTGACTGTGGA
  TGAGATTGTGGGCCAGGCCTTCATCTTCCTCATCGCTGGCTATGAAATCATCACCAACAC
  ACTTTCTTTTGCCACCTACCTACTGGCCACCAACCCTGACTGCCAAGAGAAGCTTCTGAG
  AGAGGTAGACGTTTTTAAGGAGAAACACATGGCCCCTGAGTTCTGCAGCCTCGAGGAAGG
  CCTGCCCTATCTGGACATGGTGATTGCAGAGACGCTGAGGATGTACCCGCCAGCTTTCAG
  ATTCACACGGGAGGCAGCTCAGGACTGCGAGGTGCTGGGGCAGCGCATCCCCGCAGGCGC
  TGTGCTAGAGATGGCCGTGGGTGCCCTGCACCATGACCCTGAGCACTGGCCAAGCCCGGA
  GACCTTCAACCCTGAAAGGTTCACGGCTGAGGCCCGGCAGCAGCACCGGCCCTTCACGTA
  CCTGCCCTTCGGGGCCGGCCCACGGAGCTGCCTCGGGGTGCGTCTAGGGCTGCTTGAGGT
  CAAGTTGACACTGCTCCACGTGCTGCACAAGTTCCGGTTCCAAGCCTGCCCTGAGACCCA
  GGTACCGCTGCAGCTAGAATCCAAATCTGCCCTAGGTCCAAAAAATGGTGTCTATATCAA
  GATCGTATCCCGCTGACACAGAAGGCTGCCGGGTGGGGGGAGGGCACCCCCAAATTCAAA
  GAAAACCCTAAGTGTGGATGTTCAGAATTTTGGAAAAATGTCACTGAAGTGATTGAAAGA
  GTGCCTGGCATGCAAGGATAAGAGGTTCTTTACATAACATTTCCTAAATGCTTAATAAAC
  GTTTGTTGCACTTGGTTTTGACATTGCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_001061
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001061.2, NP_001052.1
• RefSeq Size: 1946 bp
• RefSeq ORF: 1605 bp
• Locus ID: 6916
• UniProt ID: P24557
• Cytogenetics: 7q34
• Domains: p450
• Protein Families: Druggable Genome, P450
• Protein Pathways: Arachidonic acid metabolism, Metabolic pathways
• Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
  Transcript Variant: This variant (1, also known as TXS-I) encodes isoform 1, which is also known as isoform TXS-I. Both variants 1 and 3 encode the same isoform. CCDS Note: The coding region has been updated to shorten the N-terminus to one that is better supported by available conservation data and peptide data. This CCDS represents use of a downstream start codon, shortening the protein by a single amino acid.