KCNIP4 (NM_001035004) Human Untagged Clone

SKU SC322581

KCNIP4 (untagged)-Human Kv channel interacting protein 4 (KCNIP4), transcript variant 6

Product Data

• Type: Human Untagged Clone
• Target Symbol: KCNIP4
• Synonyms: CALP; KCHIP4
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322581 CCACGCGTCCGCCCACGCGTCCGCTCGAGTCTCGCTTCTGCACCCTGCGTCCCCAGACAT; GAATGTGAGGAGGGTGGAAAGCATTTCGGCTCAGCTGGAGGAGGCCAGCTCTACAGGCGG; TTTCCTGTACGCTCAGAACAGCACCAAGCGCAGCATTAAAGAGCGGCTCATGAAGCTCTT; GCCCTGCTCAGCTGCCAAAACGTCGTCTCCTGCTATTCAAAACAGCGTGGAAGATGAACT; GGAGATGGCCACCGTCAGGCATCGGCCCGAAGCCCTTGAGCTTCTGGAAGCCCAGAGCAA; ATTTACCAAGAAAGAGCTTCAGATCCTTTACAGAGGATTTAAGAACGAATGCCCCAGTGG; TGTTGTTAATGAAGAAACCTTCAAAGAGATTTACTCGCAGTTCTTTCCACAGGGAGACTC; TACAACATATGCACATTTTCTGTTCAATGCATTTGATACAGACCACAATGGAGCTGTGAG; TTTCGAGGATTTCATCAAAGGTCTTTCCATTTTGCTCCGGGGGACAGTACAAGAAAAACT; CAATTGGGCATTTAATCTGTATGACATAAATAAAGATGGCTACATCACTAAAGAGGAAAT; GCTTGATATAATGAAAGCAATATACGATATGATGGGTAAATGTACATATCCTGTCCTCAA; AGAAGATGCTCCCAGACAACACGTTGAAACATTTTTTCAGAAAATGGACAAAAATAAAGA; TGGGGTTGTTACCATAGATGAGTTCATTGAAAGCTGCCAAAAAGATGAAAACATAATGCG; CTCCATGCAGCTCTTTGAAAATGTGATTTAACTTGTCAAATAGATCCTGAATCCAACAGA; CAAATGTGAACTATTCTACCACCCTTAAAGTTGGAGCTACCACTTTTAGCATAGATTGCT; CAGCTTGACACTGAAGCATATTATGCAAACAAGCTTTGTTTTAATATAAAGCAATCCCCA; AAAGATTTGAGCTTTCAGTTATAAATTTGCATCCTTTTCATAATGCCACTGAGTTCAGGG; GATGGTCTAACTCATTTCATACTCTGTGAATATTCAAAAGTAATAGAATCTGGCATATAG; TTTTATTGGTTCCTTAGCCATGGGATTATTGAGGCTTTCACATATCAGTGATTTTAAAAT; ATCAGTGTTTTTTGCTACTCATTTGTATGTATTCAGTCCTAGGATTTTGAATGGTTTTCT; AATATAGTGACATCTGCATTTAATTTCCAGAAATTAAATTAATTTTCATGTTTGAATGCT; GTAATTCCATTTAAATTCCATTTATATACTTTAAGGAAACAAGATTACAACAATTAAAAA; AACACATAGTTCCAGTTTCTATGGCCTTCCCACCTTCTGTTAGAAATTAGTTTTATCTGG; CATTTTTAAACATTTAAAAATTATTAAACATTTAAAAATTAGTTTATTATCAGATATCAG; CATATGCCTAATAAAACTTATTTTAATAAGCAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_001035004
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001035004.1, NP_001030176.1
• RefSeq Size: 2345 bp
• RefSeq ORF: 567 bp
• Locus ID: 80333
• UniProt ID: Q6PIL6
• Cytogenetics: 4p15.31-p15.2
• Protein Families: Druggable Genome, Ion Channels: Other
• Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]; Transcript Variant: This variant (6) has an alternate exon which lacks an in-frame start codon, as compared to variant 1. Use of a downstream start codon results in an isoform (3) that has a shorter N-terminus, as compared to isoform 1. Variants 3 and 6 encode the same isoform (3).