TRAF4 (NM_004295) Human Untagged Clone

CAT#: SC320675

TRAF4 (untagged)-Human TNF receptor-associated factor 4 (TRAF4)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: TRAF4
• Synonyms: CART1; MLN62; RNF83
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004295.3 GCCCGGAGCCGGGAGCGCCGCTCCAGCGAGGCGCGGGCTGTGGGGCCGCCGCGTGCCTGG
  CCCCGCTCGCCCGTGCCGGCCGCTCGCCCGCCATGCCTGGCTTCGACTACAAGTTCCTGG
  AGAAGCCCAAGCGACGGCTGCTGTGCCCACTGTGCGGGAAGCCCATGCGCGAGCCTGTGC
  AGGTTTCCACCTGCGGCCACCGTTTCTGCGATACCTGCCTGCAGGAGTTCCTCAGTGAAG
  GAGTCTTCAAGTGCCCTGAGGACCAGCTTCCTCTGGACTATGCCAAGATCTACCCAGACC
  CGGAGCTGGAAGTACAAGTATTGGGCCTGCCTATCCGCTGCATCCACAGTGAGGAGGGCT
  GCCGCTGGAGTGGGCCACTACGTCATCTACAGGGCCACCTGAATACCTGCAGCTTCAATG
  TCATTCCCTGCCCTAATCGCTGCCCCATGAAGCTGAGCCGCCGTGATCTACCTGCACACT
  TGCAGCATGACTGCCCCAAGCGGCGCCTCAAGTGCGAGTTTTGTGGCTGTGACTTCAGTG
  GGGAGGCCTATGAGAGCCATGAGGGTATGTGCCCCCAGGAGAGTGTCTACTGTGAGAATA
  AGTGTGGTGCCCGCATGATGCGGCGGCTGCTGGCCCAGCATGCCACCTCTGAGTGCCCCA
  AGCGCACTCAGCCCTGCACCTACTGCACTAAGGAGTTCGTCTTTGACACCATCCAGAGCC
  ACCAGTACCAGTGCCCAAGGCTGCCTGTTGCCTGCCCCAACCAATGTGGTGTGGGCACTG
  TGGCTCGGGAGGACCTGCCAGGCCATCTGAAGGACAGCTGTAACACCGCCCTGGTGCTCT
  GCCCATTCAAAGACTCCGGCTGCAAGCACAGGTGCCCTAAGCTGGCAATGGCACGGCATG
  TGGAGGAGAGTGTGAAGCCACATCTGGCCATGATGTGTGCCCTGGTGAGCCGGCAACGGC
  AGGAGCTGCAGGAGCTTCGGCGAGAGCTGGAGGAGCTATCAGTGGGCAGTGATGGCGTGC
  TCATCTGGAAGATTGGCAGCTATGGACGGCGGCTACAGGAGGCCAAGGCCAAGCCCAACC
  TTGAGTGCTTCAGCCCAGCCTTCTACACACATAAGTATGGTTACAAGCTGCAGGTGTCTG
  CATTCCTCAATGGCAATGGCAGTGGTGAGGGCACACACCTCTCACTGTACATTCGTGTGC
  TGCCTGGTGCCTTTGACAATCTCCTTGAGTGGCCCTTTGCCCGCCGTGTCACCTTCTCCC
  TGCTGGATCAGAGCGACCCTGGGCTGGCTAAACCACAGCACGTCACTGAGACCTTCCACC
  CCGACCCAAACTGGAAGAATTTCCAGAAGCCAGGCACGTGGCGGGGCTCCCTGGATGAGA
  GTTCTCTGGGCTTTGGTTATCCCAAGTTCATCTCCCACCAGGACATTCGAAAGCGAAACT
  ATGTGCGGGATGATGCAGTCTTCATCCGTGCTGCTGTTGAACTGCCCCGGAAGATCCTCA
  GCTGAGTGCAGGTGGGGTTCGAGGGGAAAGGACGATGGGGCATGACCTCAGTCAGGCACT
  GGCTGAACTTGGAGAGGGGGCCGGACCCCCGTCAGCTGCTTCTGCTGCCTAGGTTCTGTT
  ACCCCATCCTCCCTCCCCCAGCCACCACCCTCAGGTGCCTCCAATTGGTGCTTCAGCCCT
  GGCCCCTGTGGGGAACAGGTCTTGGGGTCATGAAGGGCTGGAAACAAGTGACCCCAGGGC
  CTGTCTCCCTTCTTGGGTAGGGCAGACATGCCTTGGTGCCGGTCACACTCTACACGGACT
  GAGGTGCCTGCTCAGGTGCTATGTCCCAAGAGCCATAAGGGGGTGGGAATTGGGGAGGGA
  GAAAGGGTAGTTCAAAGAGTCTGTCTTGAGATCTGATTTTTTCCCCCTTTACCTAGCTGT
  GCCCCCTCTGGTTATTTATTTCCTTAGTGCCAGGAGGGCACAGCAGGGGAGCCCTGATTT
  TTAATAAATCCGGAATTGTATTTATTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  A
• Restriction Sites: Please inquire
• ACCN: NM_004295
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004295.3, NP_004286.2
• RefSeq Size: 2902 bp
• RefSeq ORF: 1413 bp
• Locus ID: 9618
• UniProt ID: Q9BUZ4
• Cytogenetics: 17q11.2
• Domains: zf-TRAF, RING, MATH
• Protein Families: Druggable Genome
• Protein Pathways: Pathways in cancer, Small cell lung cancer
• Gene Summary: This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]