Leupaxin (LPXN) (NM_004811) Human Untagged Clone

SKU SC320429

LPXN (untagged)-Human leupaxin (LPXN), transcript variant 2

Product Data

• Type: Human Untagged Clone
• Target Symbol: Leupaxin
• Synonyms: LDPL
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004811.1 CTTCTTCAGCACATGCCAAAGCTGTTCCTCACGGCCTGTGAGACAAGAGCATCTTGGATG; TAGGACAATGGAAGAGTTAGATGCCTTATTGGAGGAACTGGAACGCTCCACCCTTCAGGA; CAGTGATGAATATTCCAACCCAGCTCCTCTTCCCCTGGATCAGCATTCCAGAAAGGAGAC; TAACCTTGATGAGACTTCGGAGATCCTTTCTATTCAGGATAACACAAGTCCCTTGCCGGC; GCAGCTCGTGTATACTACCAATATCCAGGAGCTCAATGTCTACAGTGAAGCCCAAGAGCC; AAAGGAATCACCACCACCTTCTAAAACGTCAGCAGCTGCTCAGTTGGATGAGCTCATGGC; TCACCTGACTGAGATGCAGGCCAAGGTTGCAGTGAGAGCAGATGCTGGCAAGAAGCACTT; ACCAGACAAGCAGGATCACAAGGCCTCCCTGGACTCAATGCTTGGGGGTCTCGAGCAGGA; ATTGCAGGACCTTGGCATTGCCACAGTGCCCAAGGGCCATTGTGCATCCTGCCAGAAACC; GATTGCTGGGAAGGTGATCCATGCTCTAGGGCAATCATGGCATCCTGAGCATTTTGTCTG; TACTCATTGCAAAGAAGAGATTGGCTCCAGTCCCTTCTTTGAGCGGAGTGGCTTGGCCTA; CTGCCCCAACGACTACCACCAACTTTTTTCTCCACGCTGTGCTTACTGCGCTGCTCCCAT; CCTGGATAAAGTGCTGACAGCAATGAACCAGACCTGGCACCCAGAGCACTTCTTCTGCTC; TCACTGCGGAGAGGTGTTTGGTGCAGAAGGCTTTCATGAGAAGGACAAGAAGCCATATTG; CCGAAAGGATTTCTTAGCCATGTTCTCACCCAAGTGTGGTGGCTGCAATCGCCCAGTGTT; GGAAAACTACCTTTCAGCCATGGACACTGTCTGGCACCCAGAGTGCTTTGTTTGTGGGGA; CTGCTTCACCAGTTTTTCTACTGGCTCCTTCTTTGAACTGGATGGACGTCCATTCTGTGA; GCTCCATTACCATCACCGCCGGGGAACGCTCTGCCATGGGTGTGGGCAGCCCATCACTGG; CCGTTGTATCAGTGCCATGGGGTACAAGTTCCATCCTGAGCACTTTGTGTGTGCTTTCTG; CCTGACACAGTTGTCGAAGGGCATTTTCAGGGAGCAGAATGACAAGACCTATTGTCAACC; TTGCTTCAATAAGCTCTTCCCACTGTAATGCCAACTGATCCATAGCCTCTTCAGATTCCT; TATAAAATTTAAACCAAGAGAGGAGAGGAAAGGGTAAATTTTCTGTTACTGACCTTCTGC; TTAATAGTCTTATAGAAAAAGGAAAGGTGATGAGCAAATAAAGGAACTTCTAGACTTTAC; ATGACTAGGCTGATAATCTTATTTTTTAGGCTTCTATACAGTTAATTCTATAAATTCTCT; TTCTCCCTCTCTTCTCCAATCAAGCACTTGGAGTTAGATCTAGGTCCTTCTATCTCGTCC; CTCTACAGATGTATTTTCCACTTGCATAATTCATGCCAACACTGGTTTTCTTAGGTTTCT; CCATTTTCACCTCTAGTGATGGCCCTACTCATATCTTCTCTAATTTGGTCCTGATACTTG; TTTCTTTTCACGTTTTCCCATTTCCCTGTGGCTCACTGTCTTACAATCACTGCTGTGGAA; TCATGATACCACTTTTAGCTCTTTGCATCTTCCTTCAGTGTATTTTTGTTTTTCAAGAGG; AAGTAGATTTTAACTGGACAACTTTGAGTACTGACATCATTGATAAATAAACTGGCTTGT; GGTTTAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_004811
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004811.1, NP_004802.1
• RefSeq Size: 1875 bp
• RefSeq ORF: 1161 bp
• Locus ID: 9404
• UniProt ID: O60711
• Cytogenetics: 11q12.1
• Domains: LIM
• Protein Families: Druggable Genome
• Summary: The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]; Transcript Variant: This variant (2) uses an alternate 5' terminal exon, which results in a distinct 5' UTR and novel 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct N-terminus compared to isoform 1.