MOV10 (NM_020963) Human Untagged Clone

CAT#: SC320191

MOV10 (untagged)-Human Mov10, Moloney leukemia virus 10, homolog (mouse) (MOV10), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MOV10
• Synonyms: fSAP113; gb110
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_020963.1 CTCAGCTGCAGCGGCGACTTTCAGTTTCATTTCCACGGACCCTCCTGCCTGGGCCGCAGC
  CGCCGCCGCGATGCCCAGTAAGTTCAGCTGCCGGCAGCTCCGGGAGGCGGGCCAGTGTTT
  CGAGAGTTTCCTGGTCGTTCGGGGACTGGACATGGAGACAGATCGCGAGCGGCTGCGGAC
  CATTTATAACCGCGACTTCAAGATCAGCTTTGGGACCCCCGCCCCTGGCTTCTCCTCCAT
  GCTGTATGGAATGAAGATTGCAAATCTGGCCTACGTCACCAAGACTCGGGTCAGGTTCTT
  CAGACTCGACCGCTGGGCCGACGTGCGGTTCCCAGAAAAGAGGAGAATGAAGCTGGGGTC
  AGATATCAGCAAACACCACAAGTCACTGCTAGCCAAGATCTTTTATGACAGGGCTGAGTA
  TCTTCATGGGAAACATGGTGTGGATGTGGAAGTCCAGGGGCCCCATGAAGCCCGAGATGG
  GCAGCTCCTTATCCGCCTGGATTTGAACCGCAAAGAGGTGCTGACCCTGAGGCTTCGGAA
  TGGCGGAACCCAGTCTGTTACCCTCACTCACCTCTTCCCACTCTGCCGGACACCCCAGTT
  TGCTTTCTACAATGAAGACCAGGAGTTGCCCTGTCCACTGGGCCCCGGTGAATGCTATGA
  ACTCCATGTCCATTGTAAGACCAGCTTTGTGGGCTACTTCCCAGCCACAGTGCTCTGGGA
  GCTGCTGGGACCTGGGGAGTCGGGTTCAGAAGGAGCCGGCACATTCTACATTGCCCGCTT
  CTTGGCTGCCGTCGCCCACAGCCCCCTGGCTGCACAGCTGAAGCCCATGACTCCCTTCAA
  GCGGACCCGGATCACCGGAAACCCTGTGGTGACCAATCGGATAGAGGAAGGAGAGAGACC
  TGACCGCGCTAAGGGCTATGACCTGGAGTTAAGTATGGCGCTGGGGACATACTACCCACC
  TCCCCGCCTCAGGCAGCTGCTCCCCATGCTTCTTCAGGGAACAAGTATCTTCACTGCCCC
  TAAGGAGATCGCAGAGATCAAGGCCCAGCTGGAGACAGCCCTGAAGTGGAGGAACTATGA
  GGTGAAGCTGCGGCTGCTGCTGCACCTGGAGGAACTGCAGATGGAGCATGATATCCGGCA
  CTATGACCTGGAGTCGGTGCCCATGACCTGGGACCCTGTGGACCAGAACCCCAGGCTGCT
  CACGCTGGAGGTTCCTGGAGTGACTGAGAGCCGCCCCTCAGTGCTACGGGGCGACCACCT
  GTTTGCCCTTTTGTCCTCGGAGACACACCAGGAGGACCCCATCACATATAAGGGCTTTGT
  GCACAAGGTGGAATTGGACCGTGTCAAGCTGAGCTTTTCCATGAGCCTCCTGAGCCGCTT
  TGTGGATGGGCTGACCTTCAAGGTGAACTTTACCTTCAACCGCCAGCCGCTGCGAGTCCA
  GCACCGTGCCCTGGAGCTGACAGGGCGCTGGCTGCTGTGGCCCATGCTCTTTCCTGTGGC
  ACCTCGGGACGTCCCGCTGCTGCCCTCAGATGTGAAACTCAAGCTGTACGACCGGAGTCT
  GGAGTCAAACCCAGAGCAGCTGCAGGCCATGAGGCACATTGTTACGGGCACCACCCGTCC
  AGCCCCCTACATCATCTTTGGGCCTCCAGGCACCGGCAAGACTGTCACGTTAGTGGAGGC
  AATTAAGCAGGTGGTGAAGCACTTGCCCAAAGCCCACATCTTGGCCTGCGCTCCATCCAA
  CTCAGGGGCTGACCTACTCTGTCAAAGGCTCCGGGTCCACCTTCCTAGCTCCATCTACCG
  CCTCCTGGCCCCCAGCAGGGACATCCGCATGGTACCTGAGGACATCAAGCCCTGCTGCAA
  CTGGGACGCAAAGAAGGGGGAGTATGTATTTCCCGCCAAGAAGAAGCTGCAGGAATACCG
  GGTCTTAATTACCACCCTCATCACTGCCGGCAGGTTGGTCTCGGCCCAGTTTCCCATTGA
  TCACTTCACACACATCTTCATCGATGAGGCTGGCCACTGCATGGAGCCTGAGAGTCTGGT
  AGCTATAGCAGGGCTGATGGAAGTAAAGGAAACAGGTGATCCAGGAGGGCAGCTGGTGCT
  GGCAGGAGACCCTCGGCAGCTGGGGCCTGTGCTGCGTTCCCCACTGACCCAGAAGCATGG
  ACTGGGATACTCACTGCTGGAGCGGCTGCTCACCTACAACTCCCTGTACAAGAAGGGCCC
  TGATGGCTATGACCCCCAGTTCATAACCAAGCTGCTCCGCAACTACAGGTCTCATCCCAC
  CATCCTGGACATTCCTAACCAGCTCTATTATGAAGGGGAGCTGCAGGCCTGTGCTGATGT
  CGTGGATCGAGAACGCTTCTGCCGCTGGGCGGGCCTACCTCGACAGGGCTTTCCCATCAT
  CTTTCACGGCGTAATGGGCAAAGATGAGCGTGAAGGCAACAGCCCATCCTTCTTCAACCC
  TGAAGAGGCTGCCACAGTGACTTCCTACCTGAAGCTGCTCCTGGCCCCCTCCTCCAAGAA
  GGGCAAAGCTCGCCTGAGCCCTCGAAGTGTGGGCGTCATCTCCCCGTACCGGAAACAGGT
  GGAGAAAATCCGTTACTGCATCACCAAACTTGACAGGGAGCTTCGAGGACTGGATGACAT
  CAAGGACTTGAAGGTGGGTTCAGTAGAAGAATTCCAAGGCCAAGAACGAAGCGTCATCCT
  CATCTCCACCGTGCGAAGCAGCCAGAGCTTTGTGCAGCTGGATCTGGACTTTAATCTGGG
  TTTCCTTAAGAACCCCAAGAGGTTCAATGTAGCTGTGACCCGGGCCAAGGCCCTGCTCAT
  CATCGTGGGGAACCCCCTTCTCCTGGGCCATGACCCTGACTGGAAAGTATTCCTGGAGTT
  CTGTAAAGAAAACGGAGGGTATACCGGGTGTCCCTTCCCTGCCAAACTGGACCTGCAACA
  GGGACAGAATTTACTGCAAGGTCTGAGCAAGCTCAGCCCCTCTACCTCAGGGCCCCACAG
  CCATGACTACCTCCCCCAGGAGCGGGAGGGTGAAGGGGGCCTGTCTCTGCAAGTGGAGCC
  AGAGTGGAGGAATGAGCTCTGAAGACACAGCACCCAGCCTTCTCGCACCAGCCAAGCCTT
  AACTGCCTGCCTGACCCTGAACCAGAACCCAGCTGAACTGCCCCTCCAAGGGACAGGAAG
  GCTGGGGGAGGGAGTTTACAACCCAAGCCATTCCACCCCCTCCCCTGCTGGGGAGAATGA
  CACATCAAGCTGCTAACAATTGGGGGAAGGGGAAGGAAGAAAACTCTGAAAACAAAATCT
  TGTTCTATGCAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_020963
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_020963.1, NP_066014.1
• RefSeq Size: 3328 bp
• RefSeq ORF: 3012 bp
• Locus ID: 4343
• UniProt ID: Q9HCE1
• Cytogenetics: 1p13.2
• Gene Summary: 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324).[UniProtKB/Swiss-Prot Function]