MOV10 (NM_020963) Human Untagged Clone

SKU SC320191

MOV10 (untagged)-Human Mov10, Moloney leukemia virus 10, homolog (mouse) (MOV10), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: MOV10
• Synonyms: fSAP113; gb110
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_020963.1 CTCAGCTGCAGCGGCGACTTTCAGTTTCATTTCCACGGACCCTCCTGCCTGGGCCGCAGC; CGCCGCCGCGATGCCCAGTAAGTTCAGCTGCCGGCAGCTCCGGGAGGCGGGCCAGTGTTT; CGAGAGTTTCCTGGTCGTTCGGGGACTGGACATGGAGACAGATCGCGAGCGGCTGCGGAC; CATTTATAACCGCGACTTCAAGATCAGCTTTGGGACCCCCGCCCCTGGCTTCTCCTCCAT; GCTGTATGGAATGAAGATTGCAAATCTGGCCTACGTCACCAAGACTCGGGTCAGGTTCTT; CAGACTCGACCGCTGGGCCGACGTGCGGTTCCCAGAAAAGAGGAGAATGAAGCTGGGGTC; AGATATCAGCAAACACCACAAGTCACTGCTAGCCAAGATCTTTTATGACAGGGCTGAGTA; TCTTCATGGGAAACATGGTGTGGATGTGGAAGTCCAGGGGCCCCATGAAGCCCGAGATGG; GCAGCTCCTTATCCGCCTGGATTTGAACCGCAAAGAGGTGCTGACCCTGAGGCTTCGGAA; TGGCGGAACCCAGTCTGTTACCCTCACTCACCTCTTCCCACTCTGCCGGACACCCCAGTT; TGCTTTCTACAATGAAGACCAGGAGTTGCCCTGTCCACTGGGCCCCGGTGAATGCTATGA; ACTCCATGTCCATTGTAAGACCAGCTTTGTGGGCTACTTCCCAGCCACAGTGCTCTGGGA; GCTGCTGGGACCTGGGGAGTCGGGTTCAGAAGGAGCCGGCACATTCTACATTGCCCGCTT; CTTGGCTGCCGTCGCCCACAGCCCCCTGGCTGCACAGCTGAAGCCCATGACTCCCTTCAA; GCGGACCCGGATCACCGGAAACCCTGTGGTGACCAATCGGATAGAGGAAGGAGAGAGACC; TGACCGCGCTAAGGGCTATGACCTGGAGTTAAGTATGGCGCTGGGGACATACTACCCACC; TCCCCGCCTCAGGCAGCTGCTCCCCATGCTTCTTCAGGGAACAAGTATCTTCACTGCCCC; TAAGGAGATCGCAGAGATCAAGGCCCAGCTGGAGACAGCCCTGAAGTGGAGGAACTATGA; GGTGAAGCTGCGGCTGCTGCTGCACCTGGAGGAACTGCAGATGGAGCATGATATCCGGCA; CTATGACCTGGAGTCGGTGCCCATGACCTGGGACCCTGTGGACCAGAACCCCAGGCTGCT; CACGCTGGAGGTTCCTGGAGTGACTGAGAGCCGCCCCTCAGTGCTACGGGGCGACCACCT; GTTTGCCCTTTTGTCCTCGGAGACACACCAGGAGGACCCCATCACATATAAGGGCTTTGT; GCACAAGGTGGAATTGGACCGTGTCAAGCTGAGCTTTTCCATGAGCCTCCTGAGCCGCTT; TGTGGATGGGCTGACCTTCAAGGTGAACTTTACCTTCAACCGCCAGCCGCTGCGAGTCCA; GCACCGTGCCCTGGAGCTGACAGGGCGCTGGCTGCTGTGGCCCATGCTCTTTCCTGTGGC; ACCTCGGGACGTCCCGCTGCTGCCCTCAGATGTGAAACTCAAGCTGTACGACCGGAGTCT; GGAGTCAAACCCAGAGCAGCTGCAGGCCATGAGGCACATTGTTACGGGCACCACCCGTCC; AGCCCCCTACATCATCTTTGGGCCTCCAGGCACCGGCAAGACTGTCACGTTAGTGGAGGC; AATTAAGCAGGTGGTGAAGCACTTGCCCAAAGCCCACATCTTGGCCTGCGCTCCATCCAA; CTCAGGGGCTGACCTACTCTGTCAAAGGCTCCGGGTCCACCTTCCTAGCTCCATCTACCG; CCTCCTGGCCCCCAGCAGGGACATCCGCATGGTACCTGAGGACATCAAGCCCTGCTGCAA; CTGGGACGCAAAGAAGGGGGAGTATGTATTTCCCGCCAAGAAGAAGCTGCAGGAATACCG; GGTCTTAATTACCACCCTCATCACTGCCGGCAGGTTGGTCTCGGCCCAGTTTCCCATTGA; TCACTTCACACACATCTTCATCGATGAGGCTGGCCACTGCATGGAGCCTGAGAGTCTGGT; AGCTATAGCAGGGCTGATGGAAGTAAAGGAAACAGGTGATCCAGGAGGGCAGCTGGTGCT; GGCAGGAGACCCTCGGCAGCTGGGGCCTGTGCTGCGTTCCCCACTGACCCAGAAGCATGG; ACTGGGATACTCACTGCTGGAGCGGCTGCTCACCTACAACTCCCTGTACAAGAAGGGCCC; TGATGGCTATGACCCCCAGTTCATAACCAAGCTGCTCCGCAACTACAGGTCTCATCCCAC; CATCCTGGACATTCCTAACCAGCTCTATTATGAAGGGGAGCTGCAGGCCTGTGCTGATGT; CGTGGATCGAGAACGCTTCTGCCGCTGGGCGGGCCTACCTCGACAGGGCTTTCCCATCAT; CTTTCACGGCGTAATGGGCAAAGATGAGCGTGAAGGCAACAGCCCATCCTTCTTCAACCC; TGAAGAGGCTGCCACAGTGACTTCCTACCTGAAGCTGCTCCTGGCCCCCTCCTCCAAGAA; GGGCAAAGCTCGCCTGAGCCCTCGAAGTGTGGGCGTCATCTCCCCGTACCGGAAACAGGT; GGAGAAAATCCGTTACTGCATCACCAAACTTGACAGGGAGCTTCGAGGACTGGATGACAT; CAAGGACTTGAAGGTGGGTTCAGTAGAAGAATTCCAAGGCCAAGAACGAAGCGTCATCCT; CATCTCCACCGTGCGAAGCAGCCAGAGCTTTGTGCAGCTGGATCTGGACTTTAATCTGGG; TTTCCTTAAGAACCCCAAGAGGTTCAATGTAGCTGTGACCCGGGCCAAGGCCCTGCTCAT; CATCGTGGGGAACCCCCTTCTCCTGGGCCATGACCCTGACTGGAAAGTATTCCTGGAGTT; CTGTAAAGAAAACGGAGGGTATACCGGGTGTCCCTTCCCTGCCAAACTGGACCTGCAACA; GGGACAGAATTTACTGCAAGGTCTGAGCAAGCTCAGCCCCTCTACCTCAGGGCCCCACAG; CCATGACTACCTCCCCCAGGAGCGGGAGGGTGAAGGGGGCCTGTCTCTGCAAGTGGAGCC; AGAGTGGAGGAATGAGCTCTGAAGACACAGCACCCAGCCTTCTCGCACCAGCCAAGCCTT; AACTGCCTGCCTGACCCTGAACCAGAACCCAGCTGAACTGCCCCTCCAAGGGACAGGAAG; GCTGGGGGAGGGAGTTTACAACCCAAGCCATTCCACCCCCTCCCCTGCTGGGGAGAATGA; CACATCAAGCTGCTAACAATTGGGGGAAGGGGAAGGAAGAAAACTCTGAAAACAAAATCT; TGTTCTATGCAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_020963
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_020963.1, NP_066014.1
• RefSeq Size: 3328 bp
• RefSeq ORF: 3012 bp
• Locus ID: 4343
• UniProt ID: Q9HCE1
• Cytogenetics: 1p13.2
• Summary: 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324).[UniProtKB/Swiss-Prot Function]