MCL1 (NM_021960) Human Untagged Clone
MCL1 (untagged)-Human myeloid cell leukemia sequence 1 (BCL2-related) (MCL1), nuclear gene encoding mitochondrial protein, transcript variant 1
|Product Name||MCL1 (NM_021960) Human Untagged Clone|
|Synonyms||bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM|
Fully Sequenced ORF
>OriGene ORF sequence for NM_021960 edited
|ORF Size||1053 bp|
|OTI Disclaimer||Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at firstname.lastname@example.org or by calling 301.340.3188 option 3 for pricing and delivery.
The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
|OTI Annotation||The ORF of this clone has been fully sequenced and found to be a perfect match to NM_021960.3.|
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Protein Families||Transmembrane, Druggable Genome|
|Gene Summary||This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Transcript Variant: This variant (1), also known as MCL-1L (long), represents the longest transcript and encodes the longest isoform (1).
|The use of this cDNA Clones has been cited in the following citations:|
Proteasome inhibition enhances the efficacy of volasertib-induced mitotic arrest in AML in vitro and prolongs survival in vivo
,Schnerch, D;Schüler, J;Follo, M;Felthaus, J;Wider, D;Klingner, K;Greil, C;Duyster, J;Engelhardt, M;Wäsch, R;,
Oncotarget 2017,PubMed ID 28416751
FBXW7 Mediates Chemotherapeutic Sensitivity and Prognosis in NSCLC
,Yokobori, T;Yokoyama, Y;Mogi, A;Endoh, H;Altan, B;Kosaka, T;Yamaki, E;Yajima, T;Tomizawa, K;Azuma, Y;Onozato, R;Miyazaki, T;Tanaka, S;Kuwano, H;,
Mol Cancer Res. 2013 Oct 28,PubMed ID 24165483
Overexpression of Mcl-1 Confers Multidrug Resistance, Whereas Topoisomerase IIß Downregulation Introduces Mitoxantrone-Specific Drug Resistance in Acute Myeloid Leukemia
,David L. Hermanson, Sonia G. Das, Yunfang Li, and Chengguo Xing,
Mol. Pharmacol., Aug 2013; 84: 236 - 243.,PubMed ID 23696245
Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription
,Daniel Thomas, Jason A. Powell, Francois Vergez, David H. Segal, Nhu-Y. N. Nguyen, Adele Baker, Tse-Chieh Teh, Emma F. Barry, Jean-Emmanuel Sarry, Erwin M. Lee, Tracy L. Nero, Anissa M. Jabbour, Giovanna Pomilio, Benjamin D. Green, Stéphane Manenti, Stefan P. Glaser, Michael W. Parker, Angel F. Lopez, Paul G. Ekert, Richard B. Lock, David C. S. Huang, Susie K. Nilsson, Christian Récher, Andrew H. Wei, and Mark A. Guthridge,
Blood, Aug 2013; 122: 738 - 748.,PubMed ID 23775716
Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways
,Su Jung Oh, Holger H H Erb, Alfred Hobisch, Frédéric R Santer, and Zoran Culig,
Endocr. Relat. Cancer, Jun 2012; 19: 305 - 319.
N-a-Acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression
,Huiyu Xu, Beihai Jiang, Lin Meng, Tingting Ren, Yan Zeng, Jian Wu, Like Qu, and Chengchao Shou,
Carcinogenesis, Apr 2012; 10.1093/carcin/bgs144.
Mitogen-Activated Protein Kinase Inhibition Induces Translocation of Bmf to Promote Apoptosis in Melanoma
,Matthew W. VanBrocklin, Monique Verhaegen, Maria S. Soengas, and Sheri L. Holmen,
Cancer Res., Mar 2009; 69: 1985 - 1994.
|cDNA Clone Resources|