Jagged 2 (JAG2) (NM_002226) Human Untagged Clone

SKU SC315295

JAG2 (untagged)-Human jagged 2 (JAG2), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: Jagged 2
• Synonyms: HJ2; SER2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002226 edited; ATGCGGGCGCAGGGCCGGGGGCGCCTTCCCCGGCGGCTGCTGCTGCTGCTGGCGCTCTGG; GTGCAGGCGGCGCGGCCCATGGGCTATTTCGAGCTGCAGCTGAGCGCGCTGCGGAACGTG; AACGGGGAGCTGCTGAGCGGCGCCTGCTGTGACGGCGACGGCCGGACAACGCGCGCGGGG; GGCTGCGGCCACGACGAGTGCGACACGTACGTGCGCGTGTGCCTTAAGGAGTACCAGGCC; AAGGTGACGCCCACGGGGCCCTGCAGCTACGGCCACGGCGCCACGCCCGTGCTGGGCGGC; AACTCCTTCTACCTGCCGCCGGCGGGCGCTGCGGGGGACCGAGCGCGGGCGCGGGCCCGG; GCCGGCGGCGACCAGGACCCGGGCCTCGTCGTCATCCCCTTCCAGTTCGCCTGGCCGCGC; TCCTTTACCCTCATCGTGGAGGCCTGGGACTGGGACAACGATACCACCCCGAATGAGGAG; CTGCTGATCGAGCGAGTGTCGCATGCCGGCATGATCAACCCGGAGGACCGCTGGAAGAGC; CTGCACTTCAGCGGCCACGTGGCGCACCTGGAGCTGCAGATCCGCGTGCGCTGCGACGAG; AACTACTACAGCGCCACTTGCAACAAGTTCTGCCGGCCCCGCAACGACTTTTTCGGCCAC; TACACCTGCGACCAGTACGGCAACAAGGCCTGCATGGACGGCTGGATGGGCAAGGAGTGC; AAGGAAGCTGTGTGTAAACAAGGGTGTAATTTGCTCCACGGGGGATGCACCGTGCCTGGG; GAGTGCAGGTGCAGCTACGGCTGGCAAGGGAGGTTCTGCGATGAGTGTGTCCCCTACCCC; GGCTGCGTGCATGGCAGTTGTGTGGAGCCCTGGCAGTGCAACTGTGAGACCAACTGGGGC; GGCCTGCTCTGTGACAAAGACCTGAACTACTGTGGCAGCCACCACCCCTGCACCAACGGA; GGCACGTGCATCAACGCCGAGCCTGACCAGTACCGCTGCACCTGCCCTGACGGCTACTCG; GGCAGGAACTGTGAGAAGGCTGAGCACGCCTGCACCTCCAACCCGTGTGCCAACGGGGGC; TCTTGCCATGAGGTGCCGTCCGGCTTCGAATGCCACTGCCCATCGGGCTGGAGCGGGCCC; ACCTGTGCCCTTGACATCGATGAGTGTGCTTCGAACCCGTGTGCGGCCGGTGGCACCTGT; GTGGACCAGGTGGACGGCTTTGAGTGCATCTGCCCCGAGCAGTGGGTGGGGGCCACCTGC; CAGCTGGACGCCAATGAGTGTGAAGGGAAGCCATGCCTTAACGCTTTTTCTTGCAAAAAC; CTGATTGGCGGCTATTACTGTGATTGCATCCCGGGCTGGAAGGGCATCAACTGCCATATC; AACGTCAACGACTGTCGCGGGCAGTGTCAGCATGGGGGCACCTGCAAGGACCTGGTGAAC; GGGTACCAGTGTGTGTGCCCACGGGGCTTCGGAGGCCGGCATTGCGAGCTGGAACGAGAC; AAGTGTGCCAGCAGCCCCTGCCACAGCGGCGGCCTCTGCGAGGACCTGGCCGACGGCTTC; CACTGCCACTGCCCCCAGGGCTTCTCCGGGCCTCTCTGTGAGGTGGATGTCGACCTTTGT; GAGCCAAGCCCCTGCCGGAACGGCGCTCGCTGCTATAACCTGGAGGGTGACTATTACTGC; GCCTGCCCTGATGACTTTGGTGGCAAGAACTGCTCCGTGCCCCGCGAGCCGTGCCCTGGC; GGGGCCTGCAGAGTGATCGATGGCTGCGGGTCAGACGCGGGGCCTGGGATGCCTGGCACA; GCAGCCTCCGGCGTGTGTGGCCCCCATGGACGCTGCGTCAGCCAGCCAGGGGGCAACTTT; TCCTGCATCTGTGACAGTGGCTTTACTGGCACCTACTGCCATGAGAACATTGACGACTGC; CTGGGCCAGCCCTGCCGCAATGGGGGCACATGCATCGATGAGGTGGACGCCTTCCGCTGC; TTCTGCCCCAGCGGCTGGGAGGGCGAGCTCTGCGACACCAATCCCAACGACTGCCTTCCC; GATCCCTGCCACAGCCGCGGCCGCTGCTACGACCTGGTCAATGACTTCTACTGTGCGTGC; GACGACGGCTGGAAGGGCAAGACCTGCCACTCACGCGAGTTCCAGTGCGATGCCTACACC; TGCAGCAACGGTGGCACCTGCTACGACAGCGGCGACACCTTCCGCTGCGCCTGCCCCCCC; GGCTGGAAGGGCAGCACCTGCGCCGTCGCCAAGAACAGCAGCTGCCTGCCCAACCCCTGT; GTGAATGGTGGCACCTGCGTGGGCAGCGGGGCCTCCTTCTCCTGCATCTGCCGGGACGGC; TGGGAGGGTCGTACTTGCACTCACAATACCAACGACTGCAACCCTCTGCCTTGCTACAAT; GGTGGCATCTGTGTTGACGGCGTCAACTGGTTCCGCTGCGAGTGTGCACCTGGCTTCGCG; GGGCCTGACTGCCGCATCAACATCGACGAGTGCCAGTCCTCGCCCTGTGCCTACGGGGCC; ACGTGTGTGGATGAGATCAACGGGTATCGCTGTAGCTGCCCACCCGGCCGAGCCGGCCCC; CGGTGCCAGGAAGTGATCGGGTTCGGGAGATCCTGCTGGTCCCGGGGCACTCCGTTCCCA; CACGGAAGCTCCTGGGTGGAAGACTGCAACAGCTGCCGCTGCCTGGATGGCCGCCGTGAC; TGCAGCAAGGTGTGGTGCGGATGGAAGCCTTGTCTGCTGGCCGGCCAGCCCGAGGCCCTG; AGCGCCCAGTGCCCACTGGGGCAAAGGTGCCTGGAGAAGGCCCCAGGCCAGTGTCTGCGA; CCACCCTGTGAGGCCTGGGGGGAGTGCGGCGCAGAAGAGCCACCGAGCACCCCCTGCCTG; CCACGCTCCGGCCACCTGGACAATAACTGTGCCCGCCTCACCTTGCATTTCAACCGTGAC; CACGTGCCCCAGGGCACCACGGTGGGCGCCATTTGCTCCGGGATCCGCTCCCTGCCAGCC; ACAAGGGCTGTGGCACGGGACCGCCTGCTGGTGTTGCTTTGCGACCGGGCGTCCTCGGGG; GCCAGTGCCGTGGAGGTGGCCGTGTCCTTCAGCCCTGCCAGGGACCTGCCTGACAGCAGC; CTGATCCAGGGCGCGGCCCACGCCATCGTGGCCGCCATCACCCAGCGGGGGAACAGCTCA; CTGCTCCTGGCTGTCACCGAGGTCAAGGTGGAGACGGTTGTTACGGGCGGCTCTTCCACA; GGTCTGCTGGTGCCTGTGCTGTGTGGTGCCTTCAGCGTGCTGTGGCTGGCGTGCGTGGTC; CTGTGCGTGTGGTGGACACGCAAGCGCAGGAAAGAGCGGGAGAGGAGCCGGCTGCCGCGG; GAGGAGAGCGCCAACAACCAGTGGGCCCCGCTCAACCCCATCCGCAACCCCATCGAGCGG; CCGGGGGGCCACAAGGACGTGCTCTACCAGTGCAAGAACTTCACGCCGCCGCCGCGCAGG; GCGGACGAGGCGCTGCCCGGGCCGGCCGGCCACGCGGCCGTCAGGGAGGATGAGGAGGAC; GAGGATCTGGGCCGCGGTGAGGAGGACTCCCTGGAGGCGGAGAAGTTCCTCTCACACAAA; TTCACCAAAGATCCTGGCCGCTCGCCGGGGAGGCCGGCCCACTGGGCCTCAGGCCCCAAA; GTGGACAACCGCGCGGTCAGGAGCATCAATGAGGCCCGCTACGCCGGCAAGGAGTAGGGG; CGGCTGCCAGCTGGGCCGGGACCCAGGGCCCTCGGTGGGAGCCATGCCGTCTGCCGGACC; CGGAGGCCGAGGCCATGTGCATAGTTTCTTTATTTTGTGTAAAAAAACCACCAAAAACAA; AAACCAAATGTTTATTTTCTACGTTTCTTTAACCTTGTATAAATTATTCAGTAACTGTCA; GGCTGAAAACAATGGAGTATTCTCGGATAGTTGCTATTTTTGTAAAGTTTCCGTGCGTGG; CACTCGCTGTATGAAAGGAGAGAGCAAAGGGTGTCTGCGTCGTCACCAAATCGTAGCGTT; TGTTACCAGAGGTTGTGCACTGTTTACAGAATCTTCCTTTTATTCCTCACTCGGGTTTCT; CTGTGGCTCCAGGCCAAAGTGCCGGTGAGACCCATGGCTGTGTTGGTGTGGCCCATGGCT; GTTGGTGGGACCCGTGGCTGATGGTGTGGCCTGTGGCTGTCGGTGGGACTCGTGGCTGTC; AATGGGACCTGTGGCTGTCGGTGGGACCTACGGTGGTCGGTGGGACCCTGGTTATTGATG; TGGCCCTGGCTGCCGGCACGGCCCGTGGCTGTTGACGCACCTGTGGTTGTTAGTGGGGCC; TGAGGTCATCGGCGTGGCCCAAGGCCGGCAGGTCAACCTCGCGCTTGCTGGCCAGTCCAC; CCTGCCTGCCGTCTGTGCTTCCTCCTGCCCAGAACGCCCGCTCCAGCGATCTCTCCACTG; TGCTTTCAGAAGTGCCCTTCCTGCTGCGCAGTTCTCCCATCCTGGGACGGCGGCAGTATT; GAAGCTCGTGACAAGTGCCTTCACACAGACCCCTCGCAACTGTCCACGCGTGCCGTGGCA; CCAGGCGCTGCCCACCTGCCGGCCCCGGCCGCCCCTCCTCGTGAAAGTGCATTTTTGTAA; ATGTGTACATATTAAAGGAAGCACTCTGTATATTTGATTGAAAAAAAAAAAAAAAAAAAA;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002226 unedited; NGGGGTCGGCTTTTGTATACGACTCACTATAGGGCGGCCGCGATTCTGCGGGCGCAGGGC; CGGGGGCGCCTTCCCCGGCGGCTGCTGCTGCTGCTGGCGCTCTGGGTGCAGGCGGCGCGG; CCCATGGGCTATTTCGAGCTGCAGCTGAGCGCGCTGCGGAACGTGAACGGGGAGCTGCTG; AGCGGCGCCTGCTGTGACGGCGACGGCCGGACAACGCGCGCGGGGGGCTGCGGCCACGAC; GAGTGCGACACGTACGTGCGCGTGTGCCTTAAGGAGTACCAGGCCAAGGTGACGCCCACG; GGGCCCTGCAGCTACGGCCACGGCGCCACGCCCGTGCTGGGCGGCAACTCCTTCTACCTG; CCGCCGGCGGGCGCTGCGGGGGACCGAGCGCGGGCGCGGGCCCGGGCCGGCGGCGACCAG; GACCCGGGCCTCGTCGTCATCCCCTTCCAGTTCGCCTGGCCGCGCTCCTTTACCCTCATC; GTGGAGGCCTGGGACTGGGACAACGATACCACCCCGAATGAGGAGCTGCTGATCGAGCGA; GTGTCGCATGCCGGCATGATCAACCCGGAGGACCGCTGGAAGAGCCTGCACTTCAGCGGC; CACGTGGCGCACCTGGAGCTGCAGATCCGCGTGCGCTGCGACGAGAACTACTACAGCGCC; ACTTTGCACAAGTTCTGCCGGCCCCGCAACGACTTNTTCGGCCACTACACCTGCGACCAG; TACGGCAAACAGGGCCTGCATGGACCGCTGGATGGGCAANGAGTGCANGGAAGCTGTGTG; TAAACAGGGTGTAAATTGCTNCACGGGGATGCACCGTGCCTGGGGAGTGCNAGTGCACCT; ACCGCTGGCAAGGGNAGTNCTGCNATGAGTGTGTCCCCTACCCCGGCTGCGTGCATGGCA; ATTGTTTGGAGCA;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002226 unedited; CCCCATCGGGNNGATGGCAACTTGCCAGGNCCAGNAAAGCACTGGGGNAGGGTCACAGGN; ATGCCACCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGT; TTTTTTTTTTTTTTTTTTTCAATCAAATATACAGAGTGCTTCCTTTAATATGTACACATT; TACAAAAATGCACTTTCACGAGGAGGGGCGGCCGGGGCCGGCAGGTGGGCAGCGCCTGGT; GCCACGGCACGCGTGGACAGTTGCGAGGGGTCTGTGTGAAGGCACTTGTCACGAGCTTCA; ATACTGCCGCCGTCCCAGGATGGGAGAACTGCGCAGCAGGAAGGGCACTTCTGAAAGCAC; AGTGGAGAGATCGCTGGAGCGGGCGTTCTGGGCAGGAGGAAGCACAGACGGCAGGCAGGG; TGGACTGGCCAGCAAGCGCGAGGTTGACCTGCCGGCCTTGGGCCACGCCGATGACCTCAG; GCCCCACTAACAACCACAGGTGCGTCAACAGCCACGGGCCGTGCCGGCAGCCAGGGCCAC; ATCAATAACCAGGGTCCCACCGACCACCGTAGGTCCCACCGACAGCCACAGGTCCCATTG; ACAGCCACGAGTCCCACCGACAGCCACAGGCCACACCATCAGCCACGGGTCCCACCAACA; GCCATGGGCCACACCAACACAGCCATGGGTCTCACCGGCACTTTGGCCTGNAGCCACAGA; GAAACCCGAGTGAAGAATAAANGNNAGATTCTGTAAACAGTGCACAACCTNCTGGTAACA; AACGCTACGATTTTGNTGACCACGCAGACACCCTTTGCTCTCTCCTTNCATACANCGAGT; GCCACGCCACGGAAACTTACAAAAATAAGCACTATCCCAGGATACTCCATTGTTTTCAGG; CTGACAGTTACTTGAATATTTATACAAGTTTAAGAN;
• Restriction Sites: Please inquire
• ACCN: NM_002226
• Insert Size: 4700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: There is 1 nucleotide difference between the OriGene clone and the NCBI reference ORF. These result in the substitution of 1 aa and insertion of 1 aa.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002226.3, NP_002217.3
• RefSeq Size: 5077 bp
• RefSeq ORF: 3717 bp
• Locus ID: 3714
• UniProt ID: Q9Y219
• Cytogenetics: 14q32.33
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Notch signaling pathway
• Summary: The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]; Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).