STAT3 (NM_139276) Human Untagged Clone

CAT#: SC124165

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STAT3 (untagged)-Human signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1



Reconstitution Protocol

USD 1,059.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol STAT3
Synonyms ADMIO; ADMIO1; APRF; HIES
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection None
Sequence Data
>OriGene ORF sequence for NM_139276 edited
GAATTCGGCACCAGCAGGCACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGCTCGGAGAGG
CCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCGGCCTCTC
GGCCTCTGCCGGAGAAACAGTTGGGACCCCTGATTTTAGCAGGATGGCCCAATGGAATCA
GCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAGCTCTACAGTGACAGCTT
CCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGTCAAGATTGGGCATATGC
GGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGATTGACCA
GCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAGCACAATCTACGAAGAAT
CAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAGATTGCCCGGATTGTGGC
CCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCCAGCAAGG
GGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAGCAGCAGATGCTGGAGCA
GCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAGAAAATGAAAGTGGTAGA
GAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTCAAGAGTCAAGGAGACATGCA
AGATCTGAATGGAAACAACCAGTCAGTGACCAGGCAGAAGATGCAGCAGCTGGAACAGAT
GCTCACTGCGCTGGACCAGATGCGGAGAAGCATCGTGAGTGAGCTGGCGGGGCTTTTGTC
AGCGATGGAGTACGTGCAGAAAACTCTCACGGACGAGGAGCTGGCTGACTGGAAGAGGCG
GCAACAGATTGCCTGCATTGGAGGCCCGCCCAACATCTGCCTAGATCGGCTAGAAAACTG
GATAACGTCATTAGCAGAATCTCAACTTCAGACCCGTCAACAAATTAAGAAACTGGAGGA
GTTGCAGCAAAAAGTTTCCTACAAAGGGGACCCCATTGTACAGCACCGGCCGATGCTGGA
GGAGAGAATCGTGGAGCTGTTTAGAAACTTAATGAAAAGTGCCTTTGTGGTGGAGCGGCA
GCCCTGCATGCCCATGCATCCTGACCGGCCCCTCGTCATCAAGACCGGCGTCCAGTTCAC
TACTAAAGTCAGGTTGCTGGTCAAATTCCCTGAGTTGAATTATCAGCTTAAAATTAAAGT
GTGCATTGACAAAGACTCTGGGGACGTTGCAGCTCTCAGAGGATCCCGGAAATTTAACAT
TCTGGGCACAAACACAAAAGTGATGAACATGGAAGAATCCAACAACGGCAGCCTCTCTGC
AGAATTCAAACACTTGACCCTGAGGGAGCAGAGATGTGGGAATGGGGGCCGAGCCAATTG
TGATGCTTCCCTGATTGTGACTGAGGAGCTGCACCTGATCACCTTTGAGACCGAGGTGTA
TCACCAAGGCCTCAAGATTGACCTAGAGACCCACTCCTTGCCAGTTGTGGTGATCTCCAA
CATCTGTCAGATGCCAAATGCCTGGGCGTCCATCCTGTGGTACAACATGCTGACCAACAA
TCCCAAGAATGTAAACTTTTTTACCAAGCCCCCAATTGGAACCTGGGATCAAGTGGCCGA
GGTCCTGAGCTGGCAGTTCTCCTCCACCACCAAGCGAGGACTGAGCATCGAGCAGCTGAC
TACACTGGCAGAGAAACTCTTGGGACCTGGTGTGAATTATTCAGGGTGTCAGATCACATG
GGCTAAATTTTGCAAAGAAAACATGGCTGGCAAGGGCTTCTCCTTCTGGGTCTGGCTGGA
CAATATCATTGACCTTGTGAAAAAGTACATCCTGGCCCTTTGGAACGAAGGGTACATCAT
GGGCTTTATCAGTAAGGAGCGGGAGCGGGCCATCTTGAGCACTAAGCCTCCAGGCACCTT
CCTGCTAAGATTCAGTGAAAGCAGCAAAGAAGGAGGCGTCACTTTCACTTGGGTGGAGAA
GGACATCAGCGGTAAGACCCAGATCCAGTCCGTGGAACCATACACAAAGCAGCAGCTGAA
CAACATGTCATTTGCTGAAATCATCATGGGCTATAAGATCATGGATGCTACCAATATCCT
GGTGTCTCCACTGGTCTATCTCTATCCTGACATTCCCAAGGAGGAGGCATTCGGAAAGTA
TTGTCGGCCAGAGAGCCAGGAGCATCCTGAAGCTGACCCAGGTAGCGCTGCCCCATACCT
GAAGACCAAGTTTATCTGTGTGACACCAACGACCTGCAGCAATACCATTGACCTGCCGAT
GTCCCCCCGCACTTTAGATTCATTGATGCAGTTTGGAAATAATGGTGAAGGTGCTGAACC
CTCAGCAGGAGGGCAGTTTGAGTCCCTCACCTTTGACATGGAGTTGACCTCGGAGTGCGC
TACCTCCCCCATGTGAGGAGCTGAGAACGGAAGCTGCAGAAAGATACGACTGAGGCGCCT
ACCTGCATTCTGCCACCCCTCACACAGCCAAACCCCAGATCATCTGAAACTACTAACTTT
GTGGTTCCAGATTTTTTTTAATCTCCTACTTCTGCTATCTTTGAGCAATCTGGGCACTTT
TAAAAATAGAGAAATGAGTGAATGTGGGTGATCTGCTTTTATCTAAATGCAAATAAGGAT
GTGTTCTCTGAGACCCATGATCAGGGGATGTGGCGGGGGGTGGCTAGAGGGAGAAAAAGG
AAATGTCTTGTGTTGTTTTGTTCCCCTGCCCTCCTTTCTCAGCAGCTTTTTGTTATTGTT
GTTGTTGTTCTTAGACAAGTGCCTCCTGGTGCCTGCGGCATCCTTCTGCCTGTTTCTGTA
AGCAAATGCCACAGGCCACCTATAGCTACATACTCCTGGCATTGCACTTTTTAACCTTGC
TGACATCCAAATAGAAGATAGGACTATCTAAGCCCTAGGTTTCTTTTTAAATTAAGAAAT
AATAACAATTAAAGGGCAAAAAACACTGTATCAGCATAGCCTTTCTGTATTTAAGAAACT
TAAGCAGCCGGGCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGG
ATCATAAGGTCAGGAGATCAAGACCATCC
>OriGene 5' read for NM_139276 unedited
AAAAAAAAAAAAAAAAAAAAAAAAAAANNGCTGTTCACAATTGTATACGACTCCTATAGG
CGGCCGCGNAATCGGCACCAGCAGGCACCCCGGCTTGGCGCTGTCTCTCCCCCTCGGCTC
GGAGAGGCCCTTCGGCCTGAGGGAGCCTCGCCGCCCGTCCCCGGCACACGCGCAGCCCCG
GCCTCTCGGCCTCTGCCGGAGAAACAGTTGGGACCCCTGATTTTAGCAGGATGGCCCAAT
GGAATCAGCTACAGCAGCTTGACACACGGTACCTGGAGCAGCTCCATCAGCTCTACAGTG
ACAGCTTCCCAATGGAGCTGCGGCAGTTTCTGGCCCCTTGGATTGAGAGTCAAGATTGGG
CATATGCGGCCAGCAAAGAATCACATGCCACTTTGGTGTTTCATAATCTCCTGGGAGAGA
TTGACCAGCAGTATAGCCGCTTCCTGCAAGAGTCGAATGTTCTCTATCAGCACAATCTAC
GAAGAATCAAGCAGTTTCTTCAGAGCAGGTATCTTGAGAAGCCAATGGAGATTGCCCGGA
TTGTGGCCCGGTGCCTGTGGGAAGAATCACGCCTTCTACAGACTGCAGCCACTGCGGCCC
AGCAAGGGGGCCAGGCCAACCACCCCACAGCAGCCGTGGTGACGGAGAAGCAGCAGATGC
TGGAGCAGCACCTTCAGGATGTCCGGAAGAGAGTGCAGGATCTAGAACAAAAATGAAAGT
GGTAGAGAATCTCCAGGATGACTTTGATTTCAACTATAAAACCCTTAAGAGTCAAGGAGA
CATGCCAGATCTGAATGCCAACAACCAGTCAGTGACCCCGCACCAAGATGCAGCAGCTGT
AACAGATGCTCACTGCGCTCGACAGAATGCGAGAAACATCGTGAGTGAACTGCCGGGCCT
TTGTCAGCGAGTGAGCCCCGCCAA
>OriGene 3' read for NM_139276 unedited
CGATGATGCACCTTCCGGGCCGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGG
GATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTGAAACAGAATCTCAAACTGTCGCCCAGGATGGAGTGCAGTGT
GCAGTGGTGCAATTTTGGCTCACTGCAACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTG
CCTCAGCCTCCCGAGTAGCTGGGACTACAGGCCCCCACCACCCCACCCCGCTAATTTTTT
GTACTTTTAGTAAAGACGGGGTTTCACCGTGTTAGCCCGGATGGTCTTGATCTCCTGACC
TTATGATCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGG
CTGCTTAAGTTTCTTAAATACCGAAAGGCTATGCTGATACCGTGTTTTTTGCCCTTTAAT
TGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAAATAGTCCTATCTTCTATTTT
GATGTCAGCCAGGTTAAAAAGTGCAATGCCCGGAGTATGTAGCTATAGGTGGGCTGTGGC
ATTTGCTTACAAAAAACAGGCAAAAGATGCCGCACGCACCAAGAAGCACTTGTCTAAAAA
CAACAACAACAATAACAAAAAGCCTCTGAAAAAAGAGGGGCAGGGGAACAAAACACCAAC
AAAAATTTTTCTTTTTTCTTCCTTCTTACCCCCCCCACGCCACATCCCCTGGATTTCGGG
GTCTCAAAAGAAAACATTCCTTATTTTGCTTTTAGATAAAAGACAATCACACACATTTAC
TCAATTCTCCATTTTAAAAATGCCTTAGTGCCTCCCGATATTCCAATTTGGATAATAAAC
AAATTCTGCCACCCCAATTTCGTGCTCTCAAAATATCTGGGTTTCGCCCTTTTGAAGGGT
C
Restriction Sites NotI-NotI     
ACCN NM_139276
Insert Size 3384 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_139276.2, NP_644805.1
RefSeq Size 4978 bp
RefSeq ORF 2313 bp
Locus ID 6774
UniProt ID P40763
Cytogenetics 17q21.2
Domains SH2, STAT
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Acute myeloid leukemia, Adipocytokine signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer
Gene Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1).
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