CACNB1 (NM_000723) Human Untagged Clone

SKU SC123891

CACNB1 (untagged)-Human calcium channel, voltage-dependent, beta 1 subunit (CACNB1), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: CACNB1
• Synonyms: CAB1; CACNLB1; CCHLB1
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_000723, the custom clone sequence may differ by one or more nucleotides; ; ; ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTCTTCG; ACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGATGGGAGCACGTCCTC; GGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCCTACACCAGCCGTCCATCAGACTCT; GATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCG; AGAAGGCCAAGACCAAGCCAGTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGA; TGAGGTGCCTGTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATAC; AATAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCCAGCCCCGTCA; AACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGCCTCGGCTCCAGCAAATCAGG; CGATAACTCCAGTTCCAGTCTGGGAGATGTGGTGACTGGCACCCGCCGCCCCACACCCCCTGCCAGTGCC; AAACAGAAGCAGAAGTCGACAGAGCATGTGCCCCCCTATGACGTGGTGCCTTCCATGAGGCCCATCATCC; TGGTGGGACCGTCGCTCAAGGGCTACGAGGTTACAGACATGATGCAGAAAGCTTTATTTGACTTCTTGAA; GCATCGGTTTGATGGCAGGATCTCCATCACTCGTGTGACGGCAGATATTTCCCTGGCTAAGCGCTCAGTT; CTCAACAACCCCAGCAAACACATCATCATTGAGCGCTCCAACACACGCTCCAGCCTGGCTGAGGTGCAGA; GTGAAATCGAGCGAATCTTCGAGCTGGCCCGGACCCTTCAGTTGGTCGCTCTGGATGCTGACACCATCAA; TCACCCAGCCCAGCTGTCCAAGACCTCGCTGGCCCCCATCATTGTTTACATCAAGATCACCTCTCCCAAG; GTACTTCAAAGGCTCATCAAGTCCCGAGGAAAGTCTCAGTCCAAACACCTCAATGTCCAAATAGCGGCCT; CGGAAAAGCTGGCACAGTGCCCCCCTGAAATGTTTGACATCATCCTGGATGAGAACCAATTGGAGGATGC; CTGCGAGCATCTGGCGGAGTACTTGGAAGCCTATTGGAAGGCCACACACCCGCCCAGCAGCACGCCACCC; AATCCGCTGCTGAACCGCACCATGGCTACCGCAGCCCTGGCTGCCAGCCCTGCCCCTGTCTCCAACCTCC; AGGGACCCTACCTTGCTTCCGGGGACCAGCCACTGGAACGGGCCACCGGGGAGCACGCCAGCATGCACGA; GTACCCAGGGGAGCTGGGCCAGCCCCCAGGCCTTTACCCCAGCAGCCACCCACCAGGCCGGGCAGGCACG; CTACGGGCACTGTCCCGCCAAGACACTTTTGATGCCGACACCCCCGGCAGCCGAAACTCTGCCTACACGG; AGCTGGGAGACTCATGTGTGGACATGGAGACTGACCCCTCAGAGGGGCCAGGGCTTGGAGACCCTGCAGG; GGGCGGCACGCCCCCAGCCCGACAGGGATCCTGGGAGGACGAGGAAGAAGACTATGAGGAAGAGCTGACC; GACAACCGGAACCGGGGCCGGAATAAGGCCCGCTACTGCGCTGAGGGTGGGGGTCCAGTTTTGGGGCGCA; ACAAGAATGAGCTGGAGGGCTGGGGACGAGGCGTCTACATTCGCTGA; ;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000723 unedited; TACGACTGACTATAGGGCGGCCGCGAATTCGGCGCGAGGGGCAGCCGAAGGCCGAGCTGG; GTGGCTGGACCGGGTGCTGGCTGCGCCGCGCTGCTTTCGGCTCCCACGGCCGCTCCCATG; CGCTGAGGGAGCCCGGCTGGGCCGGGCCGGCGGCGGGAGGGGAGGCTCCTCTCCATGGTC; CAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATGGAGGTC; TTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGGTCAGAT; GGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCGGAGTCC; TACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCCTTAAGG; AAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCAGTGGCA; TTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCTGTGCAG; GGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATACANTAAT; GACTGGTGGATCGGNCNGCTGGTGAANGAGGGCTGTGAGGTTGCTTCATTTCCAGCCCGT; CAACTGACAGCCTCGCTGCTGANGACAGAACTGCGCAGACCNGCTCGCTCAGCAATCAGC; GATACTCAGNTCAGTCTGGAGAGTGTGCTGCAN;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000723 unedited; CCCGGCCAGGAGAGGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGATCTGTTCAGGA; AACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTGGTTTTTTTTTTTTT; TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGAGCAAAGGCCTTTGAAAGGGGGGAGTCAG; CCCCCCCTGGAGGCGAATACATGTCAGGTGTGAGCCCCTTGCTTCCTCCCCTTCCCTGGG; CTTAAAGCCCTTCCTCCCGCCGTGTGGCCCCTGCCTTTTAACGAATGTAAACGCCTTGTC; CCCAGCCCTCCAGCTTATTTTTGTTGCGCCCCAAAACTGGACCCCCACCCTCAGCGCAAT; AGCGGGCCTTATTCCGGCCCCGGTTCCGGTTGTCGGTCAACTCTTCCTCATAGTCTTCTT; CCTCGTCCTCCCAAGATCCCTGTCGGGCTGGGGGCGTGCCGCCCCCTGGAGGGTCTCCAA; GCCCTGGCCCCTCTGAGGGGTCAGTCTCCATGTCCACACATGAGTCTCCCAGCTCCGTGT; AAGCAAAATTTCCGCTGCCGGGGGTGTCGGCATCAAAAGTGTCTTGGCGGGACAATGCCC; GTATCGTGCCTGCCCGGCCTGGTGGGTGGCTTCTGGGGTAAAAGCCTGGGGGCTTGCCCA; ACTCCCCTGGTACCTGTGCATGGTGGGGTGCTCCCCGTGTGCCCTTTCATGGCTGGTCCC; CGGAACAAAGTTAGGCCCCTGGGGTTTGAAAACAGGCCAGGCTTTT;
• Restriction Sites: Please inquire
• ACCN: NM_000723
• Insert Size: 2500 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: A TrueClone.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000723.3, NP_000714.3
• RefSeq Size: 3687 bp
• RefSeq ORF: 1797 bp
• Locus ID: 782
• UniProt ID: Q02641
• Cytogenetics: 17q12
• Domains: Ca_channel_B, GuKc, SH3
• Protein Families: Druggable Genome, Ion Channels: Other
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway
• Summary: The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]; Transcript Variant: This variant (1), also known as beta-1b2, betaA, and beta-1B, encodes the longest isoform (1).