Calcipressin 1 (RCAN1) (NM_004414) Human Untagged Clone

SKU SC117406

RCAN1 (untagged)-Human regulator of calcineurin 1 (RCAN1), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: Calcipressin 1
• Synonyms: ADAPT78; CSP1; DSC1; DSCR1; MCIP1; RCN1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004414 edited; GAATTCGGCACGAGGGCCGGCCGGGCGCGGACCGGAGCGCGTGAGGCTCCGGCGCGCAAG; CCCGGAGCAGCCCGCTGGGGCGCACAGGGTCGCGCGGGCGCGGGGATGGAGGACGGCGTG; GCCGGTCCCCAGCTCGGGGCCGCGGCGGAGGCGGCGGAGGCGGCCGAGGCGCGAGCGCGG; CCCGGGGTGACGCTGCGGCCCTTCGCGCCCCTCTCGGGGGCGGCCGAGGCGGACGAGGGC; GGCGGCGACTGGAGCTTCATTGACTGCGAGATGGAGGAGGTGGACCTGCAGGACCTGCCC; AGCGCCACCATCGCCTGTCACCTGGACCCGCGCGTGTTCGTGGACGGCCTGTGCCGGGCC; AAATTTGAGTCCCTCTTTAGGACGTATGACAAGGACATCACCTTTCAGTATTTTAAGAGC; TTCAAACGAGTCAGAATAAACTTCAGCAACCCCTTCTCCGCAGCAGATGCCAGGCTCCAG; CTGCATAAGACTGAGTTTCTGGGAAAGGAAATGAAGTTATATTTTGCTCAGACCTTACAC; ATAGGAAGCTCACACCTGGCTCCGCCAAATCCAGACAAGCAGTTTCTGATCTCCCCTCCC; GCCTCTCCGCCAGTGGGATGGAAACAAGTGGAAGATGCGACCCCAGTCATAAACTATGAT; CTCTTATATGCCATCTCCAAGCTGGGGCCAGGGGAAAAGTATGAATTGCACGCAGCGACT; GACACCACTCCCAGCGTGGTGGTCCATGTATGTGAGAGTGATCAAGAGAAGGAGGAAGAA; GAGGAAATGGAAAGAATGAGGAGACCTAAGCCAAAAATTATCCAGACCAGGAGGCCGGAG; TACACGCCGATCCACCTCAGCTGAACTGGCACGCGACGAGGACGCATTCCAAATCATACT; CACGGGAGGAATCTTTTACTGTGGAGGTGGCTGGTCACGACTTCTTCGGAGGTGGCAGCC; GAGATCGGGGTGGCAGAAATCCCAGTTCATGTTGCTCAGAAGAGAATCAAGGCCGTGTCC; CCTTGTTCTAATGCTGCACACCAGTTACTGTTCATGGCACCCGGGAATGACTTGGGCCAA; TCACTGAGTTTGTGGTGATCGCACAAGGACATTTGGGACTGTCTTGAGAAAACAGATAAT; GATAGTGTTTTGTACTTGTTCTTTTCTGGTAGGTTCTGTCTGTGCCAAGGGCAGGTTGAT; CAGTGAGCTCAGGAGAGAGCTTCCTGTTTCTAAGTGGCCTGCAGGGGCCACTCTCTACTG; GTAGGAAGAGGTACCACAGGAAGCCGCCTAGTGCAGAGAGGTTGTGAAAACAGCAGCAAT; GCAATGTGGAAATTGTAGCGTTTCCTTTCTTCCCTCATGTTCTCATGTTTGTGCATGTAT; ATTACTGATTTACAAGACTAACCTTTGTTCGTATATAAAGTTACACCGTTGTTGTTTTAC; ATCTTTTGGGAAGCCAGGAAAGCGTTTGGAAAACGTATCACCTTTCCCAGATTCTCGGAT; TCTCGACTCTTTGCAACAGCACTTGCTTGCGGAACTCTTCCTGGAATGCATTCACTCAGC; ATCCCCAACCGTGCAACGTGTAACTTGTGCTTTTGCAAAAGAAGTTGATCTGAAATTCCT; CTGTAGAATTTAGCTTATACAATTCAGAGAATAGCAGTTTCACTGCCAACTTTCAGTGGG; TGAGAAATTTTAGTTTAGGTGTTTGGGATCGGACCTCAGTTTCTGTTGTTTCTTTTATGT; GGTGGTTTCTATACATGAATCATAGCCAAAAACTTTTTTGGAAACTGTTGGTTGAGATAG; TTGGTTCTTTTACCCCACGAAGACATCAAGATACACTTGTAAATAAAGCTGATAGCATAT; ATTCATACCTGTTGTACACTTGGGTGAAAAGTATGGCAGTGGGAGACTAAGATGTATTAA; CCTACCTGTGAATCATATGTTGTAGGAAAAGCTGTTCCCATGTCTAACAGGACTTGAATT; CAAAGCATGTCAAGTGGATAGTAGATCTGTGGCGATATGAGAGGGATGCAGTGCCTTTCC; CCATTCATTCCTGATGGAATTGTTATACTAGGTTAACATTTGTAATTTTTTTCTAGTTGT; AATGTGTATGTCTGGTAAATAGGTATTATATTTTGGCCTTACAATACCGTAACAATGTTT; GTCATTTTGAAATACTTAATGCCAAGTAACAATGCATGCTTTGGAAATTTGGAAGATGGT; TTTATTCTTTGAGAAGCAAATATGTTTGCATTAAATGCTTTGATTGTTCATATCAAGAAA; TTGATTGAACGTTCTCAAACCCTGTTTACGGTACTTGGTAAGAGGGAGCCGGTTTGGGAG; AGACCATTGCATCGCTGTCCAAGTGTTTCTTGTTAAGTGCTTTTAAACTGGAGAGGCTAA; CCTCAAAATATTTTTTTTAACTGCATTCTATAATAAATGGGCACAGTATGCTCCTTACAG; AAAAAAAAAAAAAAAAAACTCGAC;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004414 unedited; TGTATACGACTCACTATAGGCGGCCGCGNAATTCGCACGAGGGCCGGCCGGGCGCGGACC; GGAGCGCGTGAGGCTCCGGCGCGCAAGCCCGGAGCAGCCCGCTGGGGCGCACAGGGTCGC; GCGGGCGCGGGGATGGAGGACGGCGTGGCCGGTCCCCAGCTCGGGGCCGCGGCGGAGGCG; GCGGAGGCGGCCGAGGCGCGAGCGCGGCCCGGGGTGACGCTGCGGCCCTTCGCGCCCCTC; TCGGGGGCGGCCGAGGCGGACGAGGGCGGCGGCGACTGGAGCTTCATTGACTGCGAGATG; GAGGAGGTGGACCTGCAGGACCTGCCCAGCGCCACCATCGCCTGTCACCTGGACCCGCGC; GTGTTCGTGGACGGCCTGTGCCGGGCCAAATTTGAGTCCCTCTTTAGGACGTATGACAAG; GACATCACCTTTCAGTATTTTAAGAGCTTCAAACGAGTCAGAATAAACTTCAGCAACCCC; TTCTCCGCAGCAGATGCCAGGCTCCAGCTGCATAAGACTGAGTTTCTGGGAAAGGAAATG; AAGTTATATTTTGCTCAGACCTTACACATAGGAAGCTCACACCTGGCTCCGCCAAATCCA; GACAAGCAGTTTCTGATCTCCCCTCCCGCCTCTCCGCCAGTGGGATGGAAACAAGTGGAA; GATGCGACCCCAGTCATAAACTATGATCTCTTATATGCCATCTCCAAGCTGGGGCCAGGG; GAAAAGTATGAATTGCACGCAGCGACTGACACCACTCCCAGCGGGTGGTCCATTGTTGTG; AGAGTGATCAANAAAGGAAGGAAAAAGAGAAATGGAAAGATGAGGAGACCTAGCCAAAAT; ATCCAGACCAGAGCCGGAGTACCGCCCATCCACCTANCTGACTGCACGCGACAGGACGCA; TTCAATATACTACGGGAGGATTTTTCTGG;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004414 unedited; NNNTTTTTGCTCTGCACCGCGCGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTC; TGTAAGGAGCATACTGTGCCCATTTATTATAGAATGCAGTTAAAAAAAAATTTTGAGGTT; AGCCTCTCCAGTTTAAAAGCACTTAACAAGAAACACTTGGACAGCGATGCACTGGTCTCT; CCCAAACCGGCTCCCTCTTACCAAGTACCGTAAACAGGGTTTGAGAACGTTCAATCAATT; TCTTGATATGAACAATCAAAGCATTTAATGCAAACATATTTGCTTCTCAAAGAATAAAAC; CATCTTCCAAATTTCCAAAGCATGCATTGTTACTTGGCATTAAGTATTTCAAAATGACAA; ACATTGTTACGGTATTGTAAGGCCAAAATATAATACCTATTTACCAGACATACACATTAC; AACTAGAAAAAAATTACAAATGTTAACCTAGTATAACAATTCCATCAGGAATGAATGGGG; AAAGGCACTGCATCCCTCTCATATCGCCACAGATCTACTATCCACTTGACATGCTTTGAA; TTCAAGTCCTGTTAGACATGGGAACAGCTTTTCCTACAACATATGATTCACAGGTAGGTT; AATACATCTTAGTCTCCCACTGCCATACTTTTCACCCAAGTGTACAACAGGTATGAATAT; ATGCTATCAGCTTTATTTACAAGTGTATCTTGATGTCTTCGTGGGGTAAAAAACCAACTA; TCTCAACCAACAGTTTCCAAAAAAGTTTTTGGCTATGATTCATGTATANGAACCCCCCCA; TAAAAGAAACACCAGAACTGAGGTCCGATCCCAACACCTAAACTAAATTTTTCACCACTG; AAAGTCGCACGTGAAACTGCTATTCTCTGAATTGTATAGCTAAATTCTACAGAGGATC;
• Restriction Sites: NotI-NotI
• ACCN: NM_004414
• Insert Size: 2550 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004414.5, NP_004405.3
• RefSeq Size: 2457 bp
• RefSeq ORF: 759 bp
• Locus ID: 1827
• UniProt ID: P53805
• Cytogenetics: 21q22.12
• Domains: Calcipressin
• Protein Families: Transcription Factors
• Summary: The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]; Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).