JAB1 (COPS5) (NM_006837) Human Untagged Clone

SKU SC115830

COPS5 (untagged)-Human COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) (COPS5)

Product Data

• Type: Human Untagged Clone
• Target Symbol: JAB1
• Synonyms: CSN5; JAB1; MOV-34; SGN5
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_006837, the custom clone sequence may differ by one or more nucleotides; ; ; ATGGCGGCGTCCGGGAGCGGTATGGCCCAGAAAACCTGGGAACTGGCCAACAACATGCAGGAAGCTCAGA; GTATCGATGAAATCTACAAATACGACAAGAAACAGCAGCAAGAAATCCTGGCGGCGAAGCCCTGGACTAA; GGATCACCATTACTTTAAGTACTGCAAAATCTCAGCATTGGCTCTGCTGAAGATGGTGATGCATGCCAGA; TCGGGAGGCAACTTGGAAGTGATGGGTCTGATGCTAGGAAAGGTGGATGGTGAAACCATGATCATTATGG; ACAGTTTTGCTTTGCCTGTGGAGGGCACTGAAACCCGAGTAAATGCTCAGGCTGCTGCATATGAATACAT; GGCTGCATACATAGAAAATGCAAAACAGGTTGGCCGCCTTGAAAATGCAATCGGGTGGTATCATAGCCAC; CCTGGCTATGGCTGCTGGCTTTCTGGGATTGATGTTAGTACTCAGATGCTCAATCAGCAGTTCCAGGAAC; CATTTGTAGCAGTGGTGATTGATCCAACAAGAACAATATCCGCAGGGAAAGTGAATCTTGGCGCCTTTAG; GACATACCCAAAGGGCTACAAACCTCCTGATGAAGGACCTTCTGAGTACCAGACTATTCCACTTAATAAA; ATAGAAGATTTTGGTGTACACTGCAAACAATATTATGCCTTAGAAGTCTCATATTTCAAATCCTCTTTGG; ATCGCAAATTGCTTGAGCTGTTGTGGAATAAATACTGGGTGAATACGTTGAGTTCTTCTAGCTTGCTTAC; TAATGCAGACTATACCACTGGTCAGGTCTTTGATTTGTCTGAAAAGTTAGAGCAGTCAGAAGCCCAGCTG; GGACGAGGGAGTTTCATGTTGGGTTTAGAAACGCATGACCGAAAATCAGAAGACAAACTTGCCAAAGCTA; CAAGAGACAGCTGTAAAACTACCATAGAAGCTATCCATGGATTGATGTCTCAGGTTATTAAGGATAAACT; GTTTAATCAAATTAACATCTCTTAA; ;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_006837 unedited; AGGTTCAAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGCAAGAGTC; TAGGTAAGAGTTTGTTCCCGTGGTGCGGAGGGTCAAGGCCCACACCCGGAAACCTAGCGA; GGTGAAGTTGCGTCTTGGTTGTAGAGACGACAACTTCTCCGCTTCCTCGGCGATGGCGGC; GTCCGGGAGCGGTATGGCCCAGAAAACCTGGGAACTGGCCAACAACATGCAGGAAGCTCA; GAGTATCGATGAAATCTACAAATACGACAAGAAACAGCAGCAAGAAATCCTGGCGGCGAA; GCCCTGGACTAAGGATCACCATTACTTTAAGTACTGCAAAATCTCAGCATTGGCTCTGCT; GAAGATGGTGATGCATGCCAGATCGGGAGGCAACTTGGAAGTGATGGGTCTGATGCTAGG; AAAGGTGGATGGTGAAACCATGATCATTATGGACAGTTTTGCTTTGCCTGTGGAGGGCAC; TGAAACCCGAGTAAATGCTCAGGCTGCTGCATATGAATACATGGCTGCATACATAGAANA; TGCGAAACAGGTTGGCCGCCTTGAANATGCATCGGGTGGTATCATAGCCACCCTGGCTAT; GGCTGCTGGCTTTCTGGGATTTGATGTAGTACTCAGATGCTCAATCAGCAGTTCCAGGAA; CCATTTGTAGCAGTGGTGATTGATCCAACNNAGACATATCCGCAGGGAAGTGAATCTTGG; CGCCTTNAGACATACCCAAAAGGCTACAAACTNCTGATGAGGACCTTCTGAGTACAGACT; ATTCCACTTTATAAATAGAGATTTTGGTGTACACTGCAAACAATATATGCTTTAGAGTCT; CTATTTCAAACCCTCTTGGATCGCAAATGCTTGAGCTTGTGTGGATAAATCTGGGTGAAT; ACCTTGAGTTCTTCAAGCTGGCTACAAAGCAT;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_006837 unedited; ACTTCCAGGGCCAGNATAGCACTGGGGAGGGGTCACAGGGATGCCACCCGGGNATCTGTT; CAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCA; TTTTAAAGAGCTTTATTACAGGATATTAATATTTAGGACACTTCAGAGCACCTTATACTT; CTAATCAAATTTTGGGTAACTGGTTTTAAAGGGGTACTTGAATATTTTTCTCATACTGGC; TTTCAGGGAAAGTACTTCTCAAAGACTGTTTAAGAGATGTTAATTTGATTAAACAGTTTA; TCCTTAATAACCTGAGACATCAATCCATGGATAGCTTTTATGGTAGTTTTACAGCTGTCT; TTTGTAGCTTTGGCAAGTTTGTCTTCTGATTTTCGGTCATGCGTTTCTAAACCCAACANN; NAACTCCCTCGTCCCAGCTGGGCTTCTGACTGCTCTAACTTTTCAAACAAATCAAAGACC; TGACCAGTGGTATAGTCTGCATTAGTAAGCAAGCTAGAAAAACTCAACGTATTCACCCAG; TATTTATTCCACAACAGCTCAAGCAATTNTGCGATCCAAAGAGGATTTGAAATATGAGAC; TTCTAAGGCATAATATTGTTTGCAGTGGTCACCAAAATCTTCTATTTTATTAAGTGGAAT; AGTCTGGTACTCAGAAAGGTCCTTATCAGGAGGTTGGTAGCCCTTTGGGTATGTCCTAAA; GGCGCCCAGATTACTTTACNNNNAATATGTTTCTGGTTGATCAATCACCACTGCTACAAA; GGGGTCCTGGAACTGCTGANTGACATCTGAGTACTAACATCATCCCAAAAGNCAGCAGCC; ATAGCCAGGGTGGCTATGATACCACCCGTTGCATTTCAGGCGGGCCACCTGTTCGCATTT; CTATGTTGCAGCCTGTTTTATTAGCAGAGCCTGACAT;
• Restriction Sites: NotI-NotI
• ACCN: NM_006837
• Insert Size: 1330 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_006837.2, NP_006828.2
• RefSeq Size: 1510 bp
• RefSeq ORF: 1005 bp
• Locus ID: 10987
• UniProt ID: Q92905
• Cytogenetics: 8q13.1
• Domains: JAB_MPN
• Protein Families: Druggable Genome, Protease, Transcription Factors
• Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]