ROR1 (NM_005012) Human Tagged ORF Clone

CAT#: RC214967

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  • TrueORF®

ROR1 (Myc-DDK-tagged)-Human receptor tyrosine kinase-like orphan receptor 1 (ROR1), transcript variant 1



  "NM_005012" in other vectors (7)

Reconstitution Protocol

USD 1,287.00


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Size
    • 10 ug


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Specifications

Product Data
Type Human Tagged ORF Clone
Tag Myc-DDK
Symbol ROR1
Synonyms dJ537F10.1; NTRKR1
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>RC214967 representing NM_005012
Red=Cloning site Blue=ORF Green=Tags(s)

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGCACCGGCCGCGCCGCCGCGGGACGCGCCCGCCGCTCCTGGCGCTGCTGGCCGCGCTGCTGCTGGCCG
CACGCGGGGCTGCTGCCCAAGAAACAGAGCTGTCAGTCAGTGCTGAATTAGTGCCTACCTCATCATGGAA
CATCTCAAGTGAACTCAACAAAGATTCTTACCTGACCCTTGATGAACCAATGAATAACATCACCACGTCT
CTGGGCCAGACAGCAGAACTGCACTGCAAAGTCTCTGGGAATCCACCTCCCACCATCCGCTGGTTCAAAA
ATGATGCTCCTGTGGTCCAGGAGCCCCGGAGGCTCTCCTTTCGGTCCACCATCTATGGCTCTCGGCTGCG
GATTAGAAACCTCGACACCACAGACACAGGCTACTTCCAGTGCGTGGCAACAAACGGCAAGGAGGTGGTT
TCTTCCACTGGAGTCTTGTTTGTCAAGTTTGGCCCCCCTCCCACTGCAAGTCCAGGATACTCAGATGAGT
ATGAAGAAGATGGATTCTGTCAGCCATACAGAGGGATTGCATGTGCAAGATTTATTGGCAACCGCACCGT
CTATATGGAGTCTTTGCACATGCAAGGGGAAATAGAAAATCAGATCACAGCTGCCTTCACTATGATTGGC
ACTTCCAGTCACTTATCTGATAAGTGTTCTCAGTTCGCCATTCCTTCCCTGTGCCACTATGCCTTCCCGT
ACTGCGATGAAACTTCATCCGTCCCAAAGCCCCGTGACTTGTGTCGCGATGAATGTGAAATCCTGGAGAA
TGTCCTGTGTCAAACAGAGTACATTTTTGCAAGATCAAATCCCATGATTCTGATGAGGCTGAAACTGCCA
AACTGTGAAGATCTCCCCCAGCCAGAGAGCCCAGAAGCTGCGAACTGTATCCGGATTGGAATTCCCATGG
CAGATCCTATAAATAAAAATCACAAGTGTTATAACAGCACAGGTGTGGACTACCGGGGGACCGTCAGTGT
GACCAAATCAGGGCGCCAGTGCCAGCCATGGAATTCCCAGTATCCCCACACACACACTTTCACCGCCCTT
CGTTTCCCAGAGCTGAATGGAGGCCATTCCTACTGCCGCAACCCAGGGAATCAAAAGGAAGCTCCCTGGT
GCTTCACCTTGGATGAAAACTTTAAGTCTGATCTGTGTGACATCCCAGCTTGCGATTCAAAGGATTCCAA
GGAGAAGAATAAAATGGAAATCCTGTACATACTAGTGCCAAGTGTGGCCATTCCCCTGGCCATTGCTTTA
CTCTTCTTCTTCATTTGCGTCTGTCGGAATAACCAGAAGTCATCGTCGGCACCAGTCCAGAGGCAACCAA
AACACGTCAGAGGTCAAAATGTAGAGATGTCAATGCTGAATGCATATAAACCCAAGAGCAAGGCTAAAGA
GCTACCTCTTTCTGCTGTACGCTTTATGGAAGAATTGGGTGAGTGTGCCTTTGGAAAAATCTATAAAGGC
CATCTCTATCTCCCAGGCATGGACCATGCTCAGCTGGTTGCTATCAAGACCTTGAAAGACTATAACAACC
CCCAGCAATGGATGGAATTTCAACAAGAAGCCTCCCTAATGGCAGAACTGCACCACCCCAATATTGTCTG
CCTTCTAGGTGCCGTCACTCAGGAACAACCTGTGTGCATGCTTTTTGAGTATATTAATCAGGGGGATCTC
CATGAGTTCCTCATCATGAGATCCCCACACTCTGATGTTGGCTGCAGCAGTGATGAAGATGGGACTGTGA
AATCCAGCCTGGACCACGGAGATTTTCTGCACATTGCAATTCAGATTGCAGCTGGCATGGAATACCTGTC
TAGTCACTTCTTTGTCCACAAGGACCTTGCAGCTCGCAATATTTTAATCGGAGAGCAACTTCATGTAAAG
ATTTCAGACTTGGGGCTTTCCAGAGAAATTTACTCCGCTGATTACTACAGGGTCCAGAGTAAGTCCTTGC
TGCCCATTCGCTGGATGCCCCCTGAAGCCATCATGTATGGCAAATTCTCTTCTGATTCAGATATCTGGTC
CTTTGGGGTTGTCTTGTGGGAGATTTTCAGTTTTGGACTCCAGCCATATTATGGATTCAGTAACCAGGAA
GTGATTGAGATGGTGAGAAAACGGCAGCTCTTACCATGCTCTGAAGACTGCCCACCCAGAATGTACAGCC
TCATGACAGAGTGCTGGAATGAGATTCCTTCTAGGAGACCAAGATTTAAAGATATTCACGTCCGGCTTCG
GTCCTGGGAGGGACTCTCAAGTCACACAAGCTCTACTACTCCTTCAGGGGGAAATGCCACCACACAGACA
ACCTCCCTCAGTGCCAGCCCAGTGAGTAATCTCAGTAACCCCAGATATCCTAATTACATGTTCCCGAGCC
AGGGTATTACACCACAGGGCCAGATTGCTGGTTTCATTGGCCCGCCAATACCTCAGAACCAGCGATTCAT
TCCCATCAATGGATACCCAATACCTCCTGGATATGCAGCGTTTCCAGCTGCCCACTACCAGCCAACAGGT
CCTCCCAGAGTGATTCAGCACTGCCCACCTCCCAAGAGTCGGTCCCCAAGCAGTGCCAGTGGGTCGACTA
GCACTGGCCATGTGACTAGCTTGCCCTCATCAGGATCCAATCAGGAAGCAAATATTCCTTTACTACCACA
CATGTCAATTCCAAATCATCCTGGTGGAATGGGTATCACCGTTTTTGGCAACAAATCTCAAAAACCCTAC
AAAATTGACTCAAAGCAAGCATCTTTACTAGGAGACGCCAATATTCATGGACACACCGAATCTATGATTT
CTGCAGAACTG


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAG
GTTTAA
>RC214967 representing NM_005012
Red=Cloning site Green=Tags(s)

MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEPMNNITTS
LGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVV
SSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIG
TSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLP
NCEDLPQPESPEAANCIRIGIPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTAL
RFPELNGGHSYCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAL
LFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKG
HLYLPGMDHAQLVAIKTLKDYNNPQQWMEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDL
HEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVK
ISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQE
VIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQT
TSLSASPVSNLSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTG
PPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGITVFGNKSQKPY
KIDSKQASLLGDANIHGHTESMISAEL

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Chromatograms CHROMATOGRAMS
Sequencher program is needed, download here.
Restriction Sites SgfI-MluI      Cloning Scheme for this gene      Plasmid Map     
ACCN NM_005012
ORF Size 2811 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_005012.4
RefSeq Size 3358 bp
RefSeq ORF 2814 bp
Locus ID 4919
UniProt ID Q01973
Cytogenetics 1p31.3
Domains KR, FRI, pkinase, TyrKc, S_TKc, ig, IGc2, IG
Protein Families Druggable Genome, Protein Kinase, Transmembrane
MW 104.1 kDa
Gene Summary This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

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