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Padi4 (NM_011061) Mouse Tagged ORF Clone

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SKU
MG216758
Padi4 (tGFP-tagged) - Mouse peptidyl arginine deiminase type IV (Padi4), (10ug)
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ORF Plasmid:
tGFP DDK
AAV Particle:
DDK
  $1,130.00
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Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone
Target Symbol Padi4
Synonyms Pad4; Pdi4
Vector pCMV6-AC-GFP
E. coli Selection Ampicillin (100 ug/mL)
Mammalian Cell Selection Neomycin
Restriction Sites SgfI-MluI Cloning Scheme for this gene | Plasmid Map
ACCN NM_011061
ORF Size 1998 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_011061.2, NP_035191.2
RefSeq Size 2640 bp
RefSeq ORF 2001 bp
Locus ID 18602
UniProt ID Q9Z183
Cytogenetics 4 72.34 cM
Summary Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_011061" in other vectors (4)
SKU Description Size Price
MC220244 Padi4 (untagged) - Mouse peptidyl arginine deiminase, type IV (Padi4), (10ug) 10 ug
$611.00
MR216758 Padi4 (Myc-DDK-tagged) - Mouse peptidyl arginine deiminase, type IV (Padi4) 10 ug
$930.00
MR216758L3 Lenti ORF clone of Padi4 (Myc-DDK-tagged) - Mouse peptidyl arginine deiminase, type IV (Padi4) 10 ug
$1,230.00
MR216758L4 Lenti ORF clone of Padi4 (mGFP-tagged) - Mouse peptidyl arginine deiminase, type IV (Padi4) 10 ug
$1,230.00

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