Oasl2 (NM_011854) Mouse Untagged Clone

SKU MC202836

Oasl2 (untagged) - Mouse 2'-5' oligoadenylate synthetase-like 2 (Oasl2), (10ug)

Product Data

• Type: Mouse Untagged Clone
• Target Symbol: Oasl2
• Synonyms: M1204; Mmu-OASL; Oasl
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC034361 sequence for NM_011854; CCAGTTTCTCCAAGGAGGGAGGGGCAGAGCGCTTTTCTTCTTTCCATGCAACTCTCCATCCCACTGTCTC CTCCAGAGAACGCTGCAGGAAGCTTCTCCCATCAGAGCTGAGCAGAAGCTCAGAGGATTTATCTAGAGGA CAGGCTGGCCCAGCTGAAATGGACCCATTCCCCGACCTGTATGCGACCCCTGGGGACAGTCTAGACCACT TCCTGGAACACAGCCTTCAGCCCCAGAGGGACTGGAAAGAGGAAGGGCAGGATGCCTGGGAGAGAATCGA GAGGTTCTTTCGGGAACAGTGCTTCCGTGATGAGCTGCTCCTGGACCAAGAAGTCAGGGTGATTAAGGTG GTGAAGGGAGGCTCCTCGGGAAAGGGGACAACGCTGAACCACAGATCTGACCAAGACATGATTCTGTTCT TAAGCTGCTTTTCCAGTTTCGAAGAGCAGGCGAGAAACCGGGAGGTCGTCATCAGCTTCATTAAGAAGAG GCTGATTCATTGTAGCAGAAGCCTGGCCTACAACATCATTGTCCTTACCCACAGAGAGGGCAAAAGGACC CCTCGCTCCCTCACCCTAAAGGTTCAGTCCCGGAAGACTGATGACATTATTTGGATGGATATCCTCCCGG CTTACGATGCTTTGGGACCTATTTCCAGAGACTCAAAACCAGCACCGGCAATCTACGAGACTCTGATAAG AAGTAAGGGCTACCCTGGTGACTTCTCACCAAGCTTCACAGAGTTACAGAGACATTTTGTGAAAACTCGC CCAGTTAAACTGAAGAACCTCCTCCGGTTGGTGAAGTTCTGGTACCTGCAGTGCCTGAGACGTAAATATG GAAGAGGTGCAGTGTTGCCCTCAAAATATGCTCTGGAGCTGCTGACCATCTACGCCTGGGAGATGGGTAC AGAGAGCAGTGATAGCTTCAATCTGGATGAAGGGTTCGTAGCCGTGATGGAGCTCCTCGTAAACTACCGC GACATCTGCATCTACTGGACCAAGTACTACAATTTCCAAAACGAGGTCGTCAGGAACTTTCTGAAGAAAC AGCTGAAGGGAGACCGGCCCATCATCCTAGACCCAGCTGACCCCACCAACAACCTGGGAAGAAGAAAGGG ATGGGAACAGGTGGCTGCAGAAGCTGCTTTCTGCCTGCTGCAGGTCTGTTGCACTACTGTAGGCCCCAGC GAGCGCTGGAATGTACAGCGAGCGAGGGATGTTCAGGTGAGAGTGAAACAAACGGGAACAGTGGATTGGA CACTCTGGACAAACCCCTACAGCCCCATCAGAAAGATGAAGGCAGAGATCAGGAGGGAAAAGAACTTTGG AGGGGAACTGCGCATCTCCTTCCAGGAGCCCGGAGGGGAGAGACAGCTGCTCAGCAGCAGGAAGACCCTA GCGGATTATGGGATATTCTCTAAGGTGAACATCCAAGTGCTGGAGACCATTCCTCCTGAGATCCTGGTCT TTGTGAAGTATCCCGGTGGCCAGAGCAAGCCTTTCGCCATCGACCCTGATGATACCATCTTAGATCTGAA AGAGAAGATAGAAGATGCTGGAGGCCCTTGTGCGGAGGATCAGGTACTACTGTTGGATGATGAGGAGTTG GAAGATGATGAGAGCCTTGAAGAGCTTGAGATCAAAGACTGCGACACCATCATACTCATTAGGGTAATCG ACTAGTCTGGCTGCTTGAGTCCGTGCCTAGCGTCTTACGCCTCCCCATCTCATCCCTAGACTCTGATGGG TTCTTTCTATAGCTTAAATATCAACATCCCCTTCTCTTGCTTAAAACCCTCTCCTGTAGCCGGGCAGTGG TGGTGCATGCCTTTATCTCAGCACTTGGAGAATTTCTGAGTTCAAGGCCAGCCTGGTCTATAGAGTGAGT TGCAGGACAGCCAGAGCTATACGGAGAAACCCTGTCTCAGATAAACAAACAAACAAACAAACCCTCTCCT GTGTTTTCCAATAATACAGAATGAAGTTCAAGTTTCTTTTCCTAACAGTAAATTAAGCTGAACCCTGCTT AGTCCCCGACCCCCACTCTAAACACTCAACTCATACTGAATGCAGAGTGACACCTTGAGTCACACTGAGA GCTGAGTCACACCTGTGTCTCTTTTCCTCAAACATCCTTCCCCTCAGCCTCTGTTTTCATCATTCTGTGA GTCACTGAATCTCAAAGAGCAGACCCCAGACTGTCAGATTCCCCACCTCTCCAGAAACCTCTTAGAATGG AAAACTAACCCAAGCCAGACATTCCAACGAGACTCAGCGATCCCGGACTTAACAAGCCTTTCACATCGTT CTGCATGCTCCTGTTTGAAAACAACTACTATCTGGCCCATGCAGCAGGCCAAATCATCTTGTGTTCCCGC CCTCTCCCTTCATCCATGTTAGACTCCCGTGGACGTAAATTTATCTCCCTCGTCTAATCAGACTCGATTG TTTTTAATGATTTAGGCCTTGTGCTCTAGAATGGTACCAATCCAGTATCAATGTATGACAAGTGCTTGTT AAATAAAGAAGCGAACCAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_011854
• Insert Size: 1527 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: BC034361, AAH34361
• RefSeq Size: 2568 bp
• RefSeq ORF: 1527 bp
• Locus ID: 23962
• UniProt ID: Q9Z2F2
• Cytogenetics: 5 F
• Summary: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.[UniProtKB/Swiss-Prot Function]; Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).