Cxcr4 (NM_009911) Mouse Untagged Clone

SKU MC202204

Cxcr4 (untagged) - Mouse chemokine (C-X-C motif) receptor 4 (Cxcr4), (10ug)

Product Data

• Type: Mouse Untagged Clone
• Target Symbol: Cxcr4
• Synonyms: b2b220Clo; CD184; Cmkar4; LESTR; PB-CKR; PBSF/SDF-1; Sdf1r
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC031665 sequence for NM_009911; TGGTGCAGCAGGTAGCAGTGACCCTCTGAGGCGTTTGGTGCTCCGGTAACCACCACGGCTGTAGAGCGAG TGTTGCCATGGAACCGATCAGTGTGAGTATATACACTTCTGATAACTACTCTGAAGAAGTGGGGTCTGGA GACTATGACTCCAACAAGGAACCCTGCTTCCGGGATGAAAACGTCCATTTCAATAGGATCTTCCTGCCCA CCATCTACTTCATCATCTTCTTGACTGGCATAGTCGGCAATGGATTGGTGATCCTGGTCATGGGTTACCA GAAGAAGCTAAGGAGCATGACGGACAAGTACCGGCTGCACCTGTCAGTGGCTGACCTCCTCTTTGTCATC ACACTCCCCTTCTGGGCAGTTGATGCCATGGCTGACTGGTACTTTGGGAAATTTTTGTGTAAGGCTGTCC ATATCATCTACACTGTCAACCTCTACAGCAGCGTTCTCATCCTGGCCTTCATCAGCCTGGACCGGTACCT CGCCATTGTCCACGCCACCAACAGTCAAAGGCCAAGGAAACTGCTGGCTGAAAAGGCAGTCTATGTGGGC GTCTGGATCCCAGCCCTCCTCCTGACTATACCTGACTTCATCTTTGCCGACGTCAGCCAGGGGGACATCA GTCAGGGGGATGACAGGTACATCTGTGACCGCCTTTACCCCGATAGCCTGTGGATGGTGGTGTTTCAATT CCAGCATATAATGGTGGGTCTCATCCTGCCCGGCATCGTCATCCTCTCCTGTTACTGCATCATCATCTCT AAGCTGTCACACTCCAAGGGCCACCAGAAGCGCAAGGCCCTCAAGACGACAGTCATCCTCATCCTAGCTT TCTTTGCCTGCTGGCTGCCATATTATGTGGGGATCAGCATCGACTCCTTCATCCTTTTGGGAGTCATCAA GCAAGGATGTGACTTCGAGAGCATTGTGCACAAGTGGATCTCCATCACAGAGGCCCTCGCCTTCTTCCAC TGTTGCCTGAACCCCATCCTCTATGCCTTCCTCGGGGCCAAGTTCAAAAGCTCTGCCCAGCATGCACTCA ACTCCATGAGCAGAGGCTCCAGCCTCAAGATCCTTTCCAAAGGAAAGCGGGGTGGACACTCTTCCGTCTC CACGGAGTCAGAATCCTCCAGTTTTCACTCCAGCTAACCCTTATGCAAAGACTTATATAATATATATATA TATATGATAAAGAACCTTTTTATGTTACACATTTTCCAGATATAAGAGACTGACCAGTCTTGTACAGTTT TTTTTTTTTTTTAATTGACTGTTGGGAGTTTATGTTCCTCTAGTTTTTGTGAGGTTTGACTTAATTTATA TAAATATTGTTTTTTGTTTGTTTCATGTGAATGAGCGTCTAGGCAGGACCTGTGGCCAAGTTCTTAGTAG CTGTTTATCTGTGTGTAGGACTGTAGAACTGTAGAGGAAGAAACTGAACATTCCAGAATGTGTGGTAAAT TGAATAAAGCTAGCCGTGATCCTCAGCTGTTGCTGCATAATCTCTTCATTCCGAGGAGCACCCCACCCCC ACCCCCACCCCCACCCCATTCTTAAATTGTTTGGTTATGCTGTGTGATGGTTTGTTTGGTTTTTTTTTGT TGTTGTTGTTGTTTTTTTTTCTGTAAAAGATGGCACTTAAAACCAAAGCCTGAAATGGTGGTAGAAATGC TGGGGTTTTTTTTGTTTGTTTGTTTTTTCAGTTTTCAAGAGTAGATTGACTTCAGTCCCTACAAATGTAC AGTCTTGTATTACATTGTTAATAAAAGTCAATGATAAACTTAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_009911
• Insert Size: 1080 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: BC031665, AAH31665
• RefSeq Size: 1817 bp
• RefSeq ORF: 1080 bp
• Locus ID: 12767
• UniProt ID: P70658
• Cytogenetics: 1 56.43 cM
• Summary: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:8962122, PubMed:9295051, PubMed:9103415). Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation (PubMed:9634237, PubMed:9634238, PubMed:9689100). Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PubMed:9634237). Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (PubMed:9634238, PubMed:9689100).[UniProtKB/Swiss-Prot Function]