ERK2 (MAPK1) (NM_138957) Human 3' UTR Clone
SKU
SC201852
3' UTR clone of mitogen-activated protein kinase 1 (MAPK1) transcript variant 2 for miRNA target validation
$683.00
In Stock*
Specifications
| Product Data | |
| Vector | pMirTarget |
|---|---|
| Species | Human |
| Transfection Reporter | RFP |
| Assay Reporter | Luciferase |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Target Symbol | ERK2 |
| Synonyms | ERK; ERK-2; ERK2; ERT1; MAPK2; NS13; p38; p40; p41; p41mapk; p42-MAPK; P42MAPK; PRKM1; PRKM2 |
| ACCN | NM_138957 |
| Insert Size | 205 bp |
| Sequence Data | |
| Restriction Sites | SgfI-MluI | |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
| Components | The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_138957.2 |
| Locus ID | 5594 |
| Summary | This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. provided by RefSeq, Jan 2014 |
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Resources
Citations
MicroRNA Regulation of Mitogenic Signaling Networks in the Human Placenta
Farrokhnia, Aplin, Westwood et al
J. Biol. Chem. (2014)
Farrokhnia, Aplin, Westwood et al
J. Biol. Chem. (2014)
AI Summary: OriGene products contributed to this study by providing pmiRTarget vectors containing sense or mutated MAPK1 and MYC 3'UTR sequences, which were used in luciferase reporter assays to assess microRNA/target interactions.
Snippet: Assessment of miR/target interaction pmiRTarget vectors containing sense or mutated MAPK1 and MYC 3'UTR sequences cloned downstream of the firefly luciferase gene, and an empty vector control were purchased from OriGene Technologies (MD, USA). ... Cite SaveSaving
Showing 1-1 of 1 papers.
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