Bile Acid Receptor (NR1H4) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4F12]

SKU TA809306AM

NR1H4 mouse monoclonal antibody,clone OTI4F12, Biotinylated

Product Data

• Clone Name: OTI4F12
• Application: IHC, WB
• Recommended Dilution: WB 1:2000, IHC 1:150
• Reactivity: Human, Mouse, Rat
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant protein fragment corresponding to amino acids 21-297 of human NR1H4 (NP_005114) produced in E.coli.
• Buffer: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Biotin
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: nuclear receptor subfamily 1 group H member 4
• Database Link:
  NP_005114
  Q96RI1
• Background: This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
• Synonyms: BAR; FXR; HRR-1; HRR1; PFIC5; RIP14

Reference Data

• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors