PTEN Mouse Monoclonal Antibody [Clone ID: A8A8]

SKU TA354759

Mouse anti pTEN Monoclonal Antibody

Product Data

• Clone Name: A8A8
• Application: IHC, WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivity: Human, Mouse, Rat
• Antibody Host: Mouse
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A 403 aa of full length human pTEN recombinant protein.
• Buffer: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: ~50 kDa
• Gene Name: phosphatase and tensin homolog
• Database Link:
  NP_000305
  P60484
• Background: Thephosphatase and tensin homologue (PTEN) tumor suppressoris a phosphatidylionositol D3-phosphatase that contains the catalytic signature motif (HCXXGXXRS/T) found in all members of the protein tyrosine phosphatase family. PTEN is mutated in a wide range of cancers.In vitro, the recombinant PTEN can be regulated by phosphorylation on multiple serine and threonine residues in its C-terminus, such as CK2, GSK3beta at Ser-362, 370 and 385. It antagonizes signal transduction downstream of PI-3 kinases affecting cell proliferation, apoptosis and migration. Loss-of-function mutations in the PTEN gene lead to constitutive activation of multiple signaling pathways.
• Synonyms: 10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1

Reference Data

• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: Endometrial cancer, Focal adhesion, Glioma, Inositol phosphate metabolism, Melanoma, p53 signaling pathway, Pathways in cancer, Phosphatidylinositol signaling system, Prostate cancer, Small cell lung cancer, Tight junction