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MEIS2 Rabbit Polyclonal Antibody

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SKU
TA337288
Rabbit Polyclonal Anti-MEIS2 Antibody
Size:
100 ul
Conjugation:
Unconjugated
  $585.00
5 Days*
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View other "MEIS2 or NM_170676" antibodies

Specifications
Specifications
Product Data
Application WB
Recommended Dilution WB
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-MEIS2 antibody: synthetic peptide directed towards the middle region of human MEIS2. Synthetic peptide located within the following region: KGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHS
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purification Affinity Purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 51 kDa
Gene Name Meis homeobox 2
Database Link
Background MEIS2 encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.
Synonyms HsT18361; MRG1
Note Immunogen Sequence Homology: Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Rabbit: 100%; Zebrafish: 100%; Guinea pig: 100%
Reference Data
Protein Categories Growth Factors, Intracellular Proteins, Transciption Factors
Protein Families Transcription Factors
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Documents
Resources

file-alt Citations

MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans
VanOpstall, Perike, Brechka et al
Elife (2020) 9 DOI: 10.7554/eLife.53600
Cited by 1
AI Summary: In this study, OriGene products including the MEIS1 cDNA clone (RC210307), HOXB13 cDNA clone (RC216050), and MEIS1 shRNA lentiviral particles (TL314307V) were used to manipulate gene expression in prostate cancer cells, enabling the authors to demonstrate the tumor-suppressive role of MEIS1 and its dependence on HOXB13.
Snippet: r-posterior axis determination in combination with Homeobox (HOX) genes (Choe et al., 2014;Shanmugam et al., 1999;Williams et al., 2005). Increased expression of MEIS proteins is associated with tumorigenesis in certain cancers, including leukemia (Kumar et al., 2009), ovarian carcinoma (Crijns et al., 2007), and neuroblastoma (Geerts et al., 2005). However, in colorectal carcinoma (Crist et al
FigureFigureFigure
ChIP
Showing 1-1 of 1 papers.
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