Superoxide Dismutase 3 (SOD3) Mouse Monoclonal Antibody [Clone ID: 4GG11G6]
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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Recombinant protein of human superoxide dismutase 3, extracellular (SOD3), 20 µg
USD 867.00
Other products for "Superoxide Dismutase 3"
Specifications
Product Data | |
Clone Name | 4GG11G6 |
Applications | IF |
Recommended Dilution | WB: 1:1000, IHC: 1:100, ICC: 1:100 |
Reactivities | Human, Rat, Mouse |
Host | Mouse |
Isotype | IgG1, kappa |
Clonality | Monoclonal |
Immunogen | Human EC SOD purified from aortas |
Formulation | PBS pH7.4, 50% glycerol, 0.09% sodium azide |
Concentration | lot specific |
Purification | Protein G Purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | superoxide dismutase 3, extracellular |
Database Link | |
Background | Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body . It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase . In general, SODs play a major role in antioxidant defense mechanisms . There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge . The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space . SOD3 can also be distinguished by its heparin-binding capacity . |
Synonyms | EC-SOD |
Note | Detects EC SOD at ~35kDa. |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein |
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