IDH2 Rabbit Polyclonal Antibody

CAT#: TA319664

Rabbit Polyclonal IDH2 Antibody

Product Images

Western blot analysis of IDH2 in human heart tissue lysate with IDH2 antibody at (A) 1 and (B) 2 ug/mL.

• 

  Immunohistochemistry of IDH2 in mouse heart tissue with IDH2 antibody at 5 ug/mL.

• 

  Immunofluorescence of IDH2 in mouse heart tissue with IDH2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IDH2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human IDH2.
• Formulation: IDH2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IDH2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
• Database Link:
  NP_002159
  Entrez Gene 269951 MouseEntrez Gene 361596 RatEntrez Gene 3418 Human
  UniProt ID P48735
• Background: IDH2 Antibody: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. Both IDH1 and IDH2 play significant roles in the tricarboxylic acid cycle (TCA), and defects in IDH1 as well as IDH2 have been implicated in the development of glioma as well as other malignancies.
• Synonyms: D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH

Reference Data

• Protein Pathways: Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways