DDX58 Rabbit Polyclonal Antibody
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USD 665.00
USD 200.00
USD 867.00
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommended Dilution | RIG-1 antibody can be used for the detection of RIG-1 by Western blot at 0.5 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human and rat samples. All other applications and species not yet tested. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | RIG-1 antibody was raised against human GST-tagged RIG-1 protein. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | RIG-1 Antibody is Protein A purified. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | DEXD/H-box helicase 58 |
Database Link | |
Background | The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKKepsilon through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus. |
Synonyms | RIG-I; RIGI; RLR-1 |
Reference Data | |
Protein Pathways | Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway |
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