TDP43 (TARDBP) Rabbit Polyclonal Antibody

SKU TA301509

Rabbit Polyclonal Antibody against TARDBP

Product Data

• Application: ELISA, ICC/IF, IHC, WB
• Recommended Dilution: ELISA, Western Blot: 0.5-2 ug/ml, Immunohistochemistry: 1:250, Immunohistochemistry-Paraffin: 1:250, Immunocytochemistry/ Immunofluorescence: 1:100-1:1000
• Reactivity: Chicken, Human, Mouse, Primate, Xenopus, Zebrafish
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide to a C-terminal region [within residues 350-414] of the human TARDBP protein. [Swiss-Prot# Q13148]
• Buffer: Tris-glycine, 150mM NaCl and 0.05% sodium azide
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: TAR DNA binding protein
• Database Link:
  NP_031401
  Q13148
• Background: The HIV1 virus gives rise to acquired immunodeficiency syndrome (AIDS). HIV1 contains an RNA genome which produces chromosomally integrated DNA during cellular replication. Gene activation of HIV1 by the transactivator Tat requires an RNA regulatory element TAR which is located downstream of the transcription initiation site. TARDBP is a transcriptional repressor that binds to the chromosomally integrated TAR DNA, preventing HIV1 expression. Additionally, this protein regulates alternative splicing of the CTFR gene, a similar pseudogene on chromosoome 20. TARDBP has also been recently been shown to abnormally accumulate in the post-mortem brain tissue of individuals diagnosed with ALS (Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). This long-awaited conncection between these two diseases provides an explanation for the observed clinical overlap.
• Synonyms: ALS10; TDP-43

Reference Data

• Protein Families: Transcription Factors