CD42a (GP9) Mouse Monoclonal Antibody [Clone ID: GRP-P]

SKU SM1104P

CD42a (GP9) mouse monoclonal antibody, clone GRP-P, Purified

Product Data

• Clone Name: GRP-P
• Application: FC, IP
• Recommended Dilution: Flow Cytometry: 1/10-1/100.; Immunoprecipitation.
• Reactivity: Canine, Human, Mink
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human red blood cells and platelets. ; Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
• Specificity: This antibody recognizes the platelet GPIX glycoprotein, a 23kDa surface marker expressed by platelets and megakaryocytes. Platelet GPIX is also known as CD42a.
• Buffer: PBS, pH~7.4; State: Purified; State: Liquid purified IgG fraction; Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Ion Exchange Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: glycoprotein IX platelet
• Database Link:
  P14770
• Background: CD42a, also known as Glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and Pselectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. CD42a is present on thrombocytes and also on a so far unidentified subpopulation of T lymphocytes.
• Synonyms: Platelet glycoprotein IX, GP-IX, GP9

Reference Data