PAK4 Human shRNA Plasmid Kit (Locus ID 10298)

SKU TR320637

PAK4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 10298
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: PAK4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 10298). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001014831, NM_001014832, NM_001014833, NM_001014834, NM_001014835, NM_005884, NM_005884.1, NM_005884.2, NM_005884.3, NM_001014831.1, NM_001014831.2, NM_001014834.1, NM_001014834.2, NM_001014832.1, NM_001014835.1, NM_001014833.1, BC011368, BC011368.1, BC025282, BC025282.1, BC002921, BC034511, BM129363, NM_001014831.3, NM_001014834.3, NM_001014832.2, NM_005884.4, NM_001014835.2
• UniProt ID: O96013
• Summary: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient