MADH7 (SMAD7) Human shRNA Plasmid Kit (Locus ID 4092)

SKU TR320409

SMAD7 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 4092
• Synonyms: CRCS3; MADH7; MADH8
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: SMAD7 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 4092). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001190821, NM_001190822, NM_001190823, NM_005904, NM_005904.1, NM_005904.2, NM_005904.3, NM_001190822.1, NM_001190821.1, NM_001190823.1, BC074818, BC074818.2, BC074819
• UniProt ID: O15105
• Summary: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient