GFI1 Human shRNA Plasmid Kit (Locus ID 2672)

SKU TR312793

GFI1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 2672
• Synonyms: GFI-1; GFI1A; SCN2; ZNF163
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: GFI1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 2672). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001127215, NM_001127216, NM_005263, NM_005263.1, NM_005263.2, NM_005263.3, NM_001127215.1, NM_001127216.1, BC032751, BC032751.1, BC074866, BC074867, BM150826, NM_001127216.2, NM_001127215.2, NM_005263.5
• UniProt ID: Q99684
• Summary: This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient