HDAC5 Human shRNA Plasmid Kit (Locus ID 10014)

SKU TR312492

HDAC5 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 10014
• Synonyms: HD5; NY-CO-9
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: HDAC5 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 10014). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001015053, NM_005474, NM_139205, NM_001015053.1, NM_005474.1, NM_005474.2, NM_005474.3, NM_005474.4, BC051824, BC011260, BC013140, BC038423, BC041914, BM564861, BM998071, NM_001015053.2, NM_005474.5
• UniProt ID: Q9UQL6
• Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient