p63 (TP63) Human shRNA Plasmid Kit (Locus ID 8626)

SKU TR308688

TP63 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 8626
• Synonyms: AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: TP63 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 8626). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001114978, NM_001114979, NM_001114980, NM_001114981, NM_001114982, NM_001329144, NM_001329145, NM_001329146, NM_001329148, NM_001329149, NM_001329150, NM_001329964, NM_003722, NM_003722.1, NM_003722.2, NM_003722.3, NM_003722.4, NM_001114982.1, NM_001114981.1, NM_001114979.1, NM_001114978.1, NM_001114980.1, BC039815, BC039815.1, NM_001114979.2, NM_001114981.2, NM_003722.5, NM_001114980.2, NM_001114978.2, NM_001114982.2
• UniProt ID: Q9H3D4
• Summary: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient