ANK1 Human shRNA Plasmid Kit (Locus ID 286)

SKU TR306714

ANK1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 286
• Synonyms: ANK; SPH1; SPH2
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: ANK1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 286). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_000037, NM_001142445, NM_001142446, NM_020475, NM_020476, NM_020477, NM_020478, NM_020479, NM_020480, NM_020481, NM_020480.1, NM_020480.2, NM_020480.3, NM_020480.4, NM_020478.1, NM_020478.2, NM_020478.3, NM_020478.4, NM_020477.1, NM_020477.2, NM_020475.1, NM_020475.2, NM_000037.1, NM_000037.2, NM_000037.3, NM_020476.1, NM_020476.2, NM_001142445.1, NM_001142446.1, NM_020479.2, NM_020481.2, BC007930, BC014467, BC030957, BC117121, BC156401, NM_020476.3, NM_000037.4, NM_020478.5, NM_001142446.2, NM_001142445.2, NM_020480.5, NM_020477.3, NM_020475.3
• UniProt ID: P16157
• Summary: Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient