PACSIN1 Human shRNA Plasmid Kit (Locus ID 29993)

SKU TR302710

PACSIN1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 29993
• Synonyms: SDPI
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: PACSIN1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 29993). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001199583, NM_020804, NM_020804.1, NM_020804.3, NM_020804.4, NM_001199583.1, NM_001199583.2, BC040228, BC040228.1, BC128219, NM_020804.5
• UniProt ID: Q9BY11
• Summary: Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.[UniProtKB/Swiss-Prot Function]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient