TRAF4 Human shRNA Plasmid Kit (Locus ID 9618)

SKU TR300872

TRAF4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 9618
• Synonyms: CART1; MLN62; RNF83
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: TRAF4 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 9618). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_004295, NM_145751, NM_004295.1, NM_004295.2, NM_004295.3, BC001769, BC001769.1, BC026726, BC047358, NM_004295.4
• UniProt ID: Q9BUZ4
• Summary: This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient