ZNF93 Human shRNA Plasmid Kit (Locus ID 81931)

SKU TR300031

ZNF93 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 81931
• Synonyms: HPF34; HTF34; TF34; TF34, HPF34, HTF34, ZNF505; zinc finger protein 93; zinc finger protein 505; ZNF505
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: ZNF93 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 81931). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: BC020837, NM_001004126, NM_031218, NM_031218.1, NM_031218.2, NM_031218.3, BC038096, BC039001, BC058821, BC070372, BC107581, BC136718, BC136719, BM842045
• UniProt ID: P35789
• Summary: Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).[UniProtKB/Swiss-Prot Function]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient