Snx17 Mouse shRNA Plasmid (Locus ID 266781)

SKU TL508032

Snx17 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 266781
• Synonyms: 5830447M19Rik; AI790646; b2b1625.1Clo; D5Ertd260e; mKIAA0064
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: Snx17 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 266781). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: BC023732, BC026571, NM_153680, NM_153680.1, NM_153680.2, BC023925, BC029675
• UniProt ID: Q8BVL3
• Summary: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:12169628, PubMed:16052210). Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16052210, PubMed:18276590). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).[UniProtKB/Swiss-Prot Function]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient