Cacna1c Mouse shRNA Plasmid (Locus ID 12288)

SKU TL500242

Cacna1c - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 12288
• Synonyms: Cav1.2; Cchl1a1; D930026N18Rik; MBC; MELC-CC
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: Cacna1c - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 12288). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001159533, NM_001159534, NM_001159535, NM_001255997, NM_001255998, NM_001255999, NM_001256000, NM_001256001, NM_001256002, NM_001290335, NM_009781, NM_009781.1, NM_009781.2, NM_009781.3, NM_009781.4, NM_001159533.1, NM_001159533.2, NM_001159535.1, NM_001159535.2, NM_001290335.1, NM_001256000.1, NM_001256000.2, NM_001256001.1, NM_001256001.2, NM_001255997.1, NM_001255997.2, NM_001255999.1, NM_001255999.2, NM_001255998.1, NM_001255998.2, NM_001256002.1, NM_001256002.2, NM_001159534.1, BC145104, BC138031, BC094579, BC145103, BC145105
• UniProt ID: Q01815
• Summary: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:14609949, PubMed:18586882, PubMed:21216955, PubMed:25368181, PubMed:28119464). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:21216955). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:14609949, PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).[UniProtKB/Swiss-Prot Function]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient