Thymine DNA glycosylase (TDG) Human shRNA Plasmid Kit (Locus ID 6996)

SKU TL316755

TDG - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 6996
• Synonyms: E130317C12Rik; JZA-3; Jza1; OTTMUSP00000028912; OTTMUSP00000028913; thymine DNA glycosylase
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: TDG - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 6996). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001008411, NM_003211, NM_003211.1, NM_003211.2, NM_003211.3, NM_003211.4, BC037557, BC037557.1, BC001307, BC010945, BC019925, BC071714, BC104477, NM_001363612
• UniProt ID: Q13569
• Summary: The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient