beta Catenin (CTNNB1) Human shRNA Plasmid Kit (Locus ID 1499)

SKU TL313664

CTNNB1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 1499
• Synonyms: armadillo; CTNNB; EVR7; MRD19; NEDSDV
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: CTNNB1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 1499). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001098209, NM_001098210, NM_001904, NM_001330729, NM_001904.1, NM_001904.2, NM_001904.3, NM_001098209.1, NM_001098210.1, BC058926, BC058926.1, NM_001098210.2, NM_001098209.2, NM_001904.4
• UniProt ID: P35222
• Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient