Ikaros (IKZF1) Human shRNA Plasmid Kit (Locus ID 10320)

SKU TL308127

IKZF1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 10320
• Synonyms: CVID13; Hs.54452; IK1; IKAROS; LyF-1; LYF1; PPP1R92; PRO0758; ZNFN1A1
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: IKZF1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 10320). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001220765, NM_001220766, NM_001220767, NM_001220768, NM_001220769, NM_001220770, NM_001220771, NM_001220772, NM_001220773, NM_001220774, NM_001220775, NM_001220776, NM_001291837, NM_001291838, NM_001291839, NM_001291840, NM_001291841, NM_001291842, NM_001291843, NM_001291844, NM_001291845, NM_001291846, NM_001291847, NM_006060, NM_006060.1, NM_006060.2, NM_006060.3, NM_006060.4, NM_006060.5, NM_001220772.1, NM_001220776.1, NM_001220775.1, NM_001220774.1, NM_001220773.1, NM_001220771.1, NM_001220771.2, NM_001220770.1, NM_001220770.2, NM_001220769.1, NM_001220767.1, NM_001220767.2, NM_001220766.1, NM_001220768.1, NM_001220768.2, NM_001220765.1, NM_001220765.2, NM_001291846.1, NM_001291847.1, NM_001291845.1, NM_001291840.1, NM_001291844.1, NM_001291843.1, NM_001291842.1, NM_001291841.1, NM_001291839.1, NM_001291838.1, NM_001291837.1, BC018349, BC064594, BC075820, BM148203, NM_001291837.2, NM_001291838.2, NM_006060.6, NM_001291839.2, NM_001220765.3, NM_001291847.2, NM_001291846.2, NM_001291845.2
• UniProt ID: Q13422
• Summary: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient