Calpain 10 (CAPN10) Human shRNA Plasmid Kit (Locus ID 11132)

SKU TL305662

CAPN10 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 11132
• Synonyms: calcium-activated neutral protease; calpain 10; NIDDM1; OTTHUMP00000164509
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: CAPN10 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 11132). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_021251, NM_023083, NM_023084, NM_023085, NM_023086, NM_023087, NM_023088, NM_023089, NM_023083.1, NM_023083.2, NM_023085.1, NM_023085.2, NM_023085.3, NM_021251.2, NM_023089.1, BC004260, BC004260.1, BC007553, BC107088
• UniProt ID: Q9HC96
• Summary: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient