Geminin (GMNN) Human shRNA Plasmid Kit (Locus ID 51053)

SKU TL304304

GMNN - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 51053
• Synonyms: Gem; MGORS6
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: GMNN - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 51053). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001251989, NM_001251990, NM_001251991, NM_015895, NM_015895.1, NM_015895.2, NM_015895.3, NM_015895.4, NM_001251989.1, NM_001251990.1, NM_001251991.1, BC005389, BC005389.1, BC005185, BM699599, NM_001251989.2, NM_001251990.2, NM_015895.5
• UniProt ID: O75496
• Summary: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient