MBNL1 Human shRNA Plasmid Kit (Locus ID 4154)

SKU TL303325

MBNL1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 4154
• Synonyms: EXP; MBNL
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: MBNL1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 4154). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001314057, NM_021038, NM_207292, NM_207293, NM_207294, NM_207295, NM_207296, NM_207297, NM_021038.1, NM_021038.2, NM_021038.3, NM_021038.4, NM_207295.1, NM_207292.1, NM_207292.2, NM_207293.1, NM_207294.1, NM_207297.1, NM_207296.1, BC043493, BC043493.1, BC005296, BC050535, BM686432, NM_001363870, NM_207297.2, NM_207292.3, NM_021038.5, NM_207293.2, NM_207294.2, NM_207296.2, NM_207295.2
• UniProt ID: Q9NR56
• Summary: This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities. [provided by RefSeq, Sep 2015]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient