Mef2c Mouse shRNA Plasmid (Locus ID 17260)

SKU TG511428

Mef2c - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 17260
• Synonyms: 5430401D19Rik; 9930028G15Rik; AV011172; Mef2
• Vector: pGFP-V-RS
• E. coli Selection: Kan
• Format: Retroviral plasmids
• Components: Mef2c - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 17260). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
• RefSeq: BC026841, BC037731, BC057650, NM_001170537, NM_001347564, NM_001347566, NM_001347567, NM_001347568, NM_001347569, NM_001347571, NM_001347572, NM_001347573, NM_001347574, NM_001347575, NM_001347576, NM_001347577, NM_001347578, NM_001347579, NM_001347580, NM_001347581, NM_025282, NM_025282.1, NM_025282.2, NM_025282.3, NM_001170537.1
• UniProt ID: Q8CFN5
• Summary: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18 (PubMed:11554755). May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells.[UniProtKB/Swiss-Prot Function]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient